Reference levels of blood mercury and association with metabolic syndrome in Korean adults
Reference levels of blood mercury and association with metabolic syndrome in Korean adults
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DOI：
10.1007/s00420-013-0891-8
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发表时间：
2014-07-01
影响因子：
3
通讯作者：
Park, Jung-Duck
中科院分区：
文献类型：
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作者：
Eom, Sang-Yong;Choi, Sun-Hee;Park, Jung-Duck
汞（Hg）是一种非必需的有毒金属，广泛分布于环境中。本研究旨在估计韩国成年人的代表性血汞水平，确定汞暴露的影响因素，并分析血汞与代谢综合征的关系。汞暴露是通过血液中汞的总浓度来评估的。采用多阶段、性别和年龄分层概率方法，对2,114名未职业性接触过汞的健康成年人进行了抽样。收集有关受试者的人口统计学特征、生活方式和既往病史的信息。参与者随后接受了身体检查和血液采样。全血汞几何平均浓度为3.90 μ g/L，经混杂因素校正后，受性别、年龄、吸烟、饮酒、居住地、海鲜摄入量等因素影响显著。根据调整协变量后的血汞水平，观察到体重指数、腰围、舒张压、总胆固醇和甘油三酯显著增加。此外，汞暴露与代谢综合征及其组成部分（如肥胖和空腹血糖升高）显著相关。韩国成年人的血汞水平高于美国等西方国家，而与亚洲其他国家相近或较低。血汞水平受社会人口因素和个人生活方式（包括饮食习惯）的影响。此外，血汞与代谢综合征有关，其中汞暴露可能是心血管疾病的一个可能的危险因素。
Mercury (Hg) is a nonessential and toxic metal that is widely distributed in the environment. This study was performed to estimate the representative blood Hg level, to determine the contributing factors to Hg exposure, and to analyze the association of blood Hg with metabolic syndrome in Korean adults.Mercury exposure is assessed by total Hg concentration in blood. A total of 2,114 healthy adults who have not been exposed to Hg occupationally were sampled by the multistaged, sex-, and age-stratified probability method. Information was collected regarding the subjects' demographic characteristics, lifestyles, and past medical history. The participants then underwent physical examination and blood sampling.The geometric mean concentration of Hg in whole blood was 3.90 mu g/L, which was significantly influenced by sex, age, smoking, alcoholic consumption, residence area, and seafood intake after adjustment for confounders. Significant increases in body mass index, waist circumference, diastolic blood pressure, total cholesterol, and triglyceride were observed according to the blood Hg levels after adjustment for covariates. Also, Hg exposure was significantly associated with metabolic syndrome and their components such as obesity and increased fasting glucose.The blood Hg level in Korean adults is higher than that in USA and other Western countries, while it is similar to or lower than that in other Asian countries. The blood Hg level is influenced by sociodemographic factors and individual lifestyles including dietary habits. Furthermore, blood Hg is associated with metabolic syndrome, in which Hg exposure may play a role as a possible risk factor for cardiovascular diseases.