Borderline and cluster C personality disorders manifest distinct physiological responses to psychosocial stress
Borderline and cluster C personality disorders manifest distinct physiological responses to psychosocial stress
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DOI：
10.1016/j.psyneuen.2016.06.010
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发表时间：
2016-10-01
影响因子：
3.7
通讯作者：
Kushner, Steven A.
中科院分区：
文献类型：
--
作者：
Aleknaviciute, Jurate;Tulen, Joke H. M.;Kushner, Steven A.
背景：适应不良的情绪控制是人格障碍的一个特征。然而，人们对不同人格障碍对心理社会压力的情绪反应的潜在生理动力学知之甚少。当前的研究比较了患有C群人格障碍（CPD）和边缘性人格障碍（BPD）的女性对心理社会压力的主观情绪反应与自主神经系统和HPA轴的生理反应。方法：在治疗前、治疗中、治疗结束后，在暴露于标准化的心理社会应激范式（Trier社会应激测试，TSST）后，26名BPD女性，20名CPD女性和35名健康女性对照。受试者是免费的任何药物，包括激素避孕药，有规律的月经周期，并在黄体期的月经cycle.Results：CPD和BPD患者报告了类似的负担主观情绪障碍。然而，只有BPD患者表现出基线皮质醇水平降低，皮质醇和HR对TSST的反应性减弱。此外，BPD患者表现出SCL的普遍增加。CPD患者与健康对照组相比，TSST反应性、皮质醇反应性、HR反应性、SCL反应性均无显著性差异。结论：BPD患者的生理应激反应性发生显著改变，与CPD患者和健康对照组相比有显著性差异。(C)2016爱思唯尔有限公司版权所有
Background: Maladaptive emotional control is a defining feature of personality disorders. Yet little is known about the underlying physiological dynamics of emotional reactivity to psychosocial stress across distinct personality disorders. The current study compared subjective emotional responses with autonomic nervous system and HPA axis physiological responses to psychosocial stress in women with cluster C personality disorder (CPD) and borderline personality disorder (BPD).Methods: Subjective mood ratings, salivary cortisol, heart rate (HR), and skin conductance level (SCL) were assessed before, during, and after exposure to a standardized psychosocial stress paradigm (Trier Social Stress Test, TSST) in 26 women with BPD, 20 women with CPD, and 35 healthy female controls. Subjects were free of any medication including hormonal contraceptives, had a regular menstrual cycle, and were tested during the luteal phase of their menstrual cycle.Results: Both CPD and BPD patients reported a similar burden of subjective mood disturbance. However, only BPD patients demonstrated reduced baseline cortisol levels with a blunted cortisol and HR reactivity to the TSST. In addition, BPD patients exhibited a generalized increase of SCL. No significant differences in baseline or TSST reactivity of cortisol, HR, or SCL were observed between CPD patients and healthy controls.Conclusion: These findings indicate that patients with BPD have significant alterations in their physiological stress reactivity, which is notably distinct from patients with CPD and those of healthy controls. (C) 2016 Elsevier Ltd. All rights reserved.