Estrogen receptor alpha and beta in health and disease
Estrogen receptor alpha and beta in health and disease
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DOI：
10.1016/j.beem.2015.04.008
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发表时间：
2015-08-01
影响因子：
7.4
通讯作者：
Gustafsson, Jan-Ake
中科院分区：
文献类型：
--
作者：
Jia, Min;Dahlman-Wright, Karin;Gustafsson, Jan-Ake
雌激素受体α (ER α)和β (ER β)是参与调节人类许多复杂生理过程的转录因子。异常的内质网信号可导致多种疾病的发生，如癌症、代谢和心血管疾病、神经退行性疾病、炎症和骨质疏松症。本文综述了内质网α和内质网β在健康和疾病中的最新进展，重点介绍了它们在癌症和代谢性疾病中的作用，以及近年来成功提供内质网功能全基因组数据的背景。此外，还讨论了潜在的临床应用和挑战。(C) 2015 Elsevier Ltd.版权所有。
Estrogen receptors alpha (ER alpha) and beta (ER beta) are transcription factors that are involved in the regulation of many complex physiological processes in humans. Abnormal ER signaling leads to development of a variety of diseases, such as cancer, metabolic and cardiovascular disease, neurodegeneration, inflammation, and osteoporosis. This review provides an overview and update on ER alpha and ER beta in health and disease with focus on their role in cancer and metabolic disease and in the context of recent years' success in providing genome wide data on ER function. Furthermore, potential clinical applications and challenges are also discussed. (C) 2015 Elsevier Ltd. All rights reserved.