Unexpectedly high variability of the histone H4 gene in Leishmania.
Unexpectedly high variability of the histone H4 gene in Leishmania.
复制标题
利什曼原虫中组蛋白 H4 基因的意外高变异性。
DOI：
10.1007/s004360050040
复制
发表时间：
2000
影响因子：
2
通讯作者：
Maslov,DA
中科院分区：
文献类型：
--
作者：
Lukes,J;Maslov,DA
The sequence of the cDNA of the histone H4 gene ofLeishmania tarentolaeis reported herein. The predicted 100-amino-acid-long protein has the highest degree of identity with the histone H4 gene ofL. infantumand shares with it a 5′ region that shows a very low degree of identity with the corresponding region of histone H4 genes from other organisms. However, between these two genes is a 7.7% nucleotide difference that results in seven different amino acids, located in the 5′, central, and 3′ regions of the coding sequence. Such a divergence in the H4 gene, which is considered to be one of the most highly conserved genes, between closely related members of the genusLeishmaniais unexpected and may reflect some unusual features of these important proteins in kinetoplastid flagellates.
