Changes in glycoprotein carbohydrate content in the aging human brain
Changes in glycoprotein carbohydrate content in the aging human brain
复制标题
衰老人脑中糖蛋白碳水化合物含量的变化
DOI：
10.1007/bf00965327
复制
发表时间：
1986
影响因子：
4.4
通讯作者：
J. C. Webster
中科院分区：
文献类型：
--
作者：
E. Brunngraber;J. C. Webster
随着人脑年龄从25岁到85岁，每克新鲜组织中与脑糖蛋白相关的总碳水化合物的浓度没有显著变化。然而，不同类型的低聚糖的浓度确实发生了显著的变化。从全脑中回收的总糖肽-碳水化合物的浓度和百分比（以三触角和四触角类型的N-糖苷键连接的复合唾液酸低聚糖为代表）显示出随着年龄的增长而显着下降。另一方面，卵清蛋白型的N-连接的甘露糖高寡糖、转铁蛋白型的N-连接的双触角唾液酸糖肽和O-连接的寡糖显示出随着脑年龄的增加而增加。观察到的其他年龄相关变化包括与N-连接唾液酸糖肽相关的硫酸酯基团数量增加和磷酸化高甘露糖寡糖数量减少。
There is no significant change in the concentration, per gram of fresh tissue, of the total carbohydrate associated with brain glycoproteins as the human brain ages from 25 to 85 years. Nevertheless, notable shifts in the concentration of varied types of oligosaccharides do occur. The concentration and percentage of total glycopeptide-carbohydrate recovered from the whole brain represented by the N-glycosidically linked complex siablooligosaccharides of the tri-and tetraantennary type show a marked decline with age. On the other hand, the N-linked mannose high oligosaccharides of the ovalbumin type, the N-linked biantennary sialoglycopeptides of the transferrin type, and the O-linked oligosaccharides show an increase as the brain ages. Other age related changes that were noted include an increase in the number of sulfate ester groups associated with the N-linked sialoglycopeptides and a decrease in the number of phosphorylated high mannose oligosaccharides as the brain ages.