Antioxidative therapeutic strategies for Parkinson's disease.
Antioxidative therapeutic strategies for Parkinson's disease.
复制标题
帕金森病的抗氧化治疗策略。
DOI：
10.1111/j.1749-6632.1992.tb24522.x
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发表时间：
1992
影响因子：
5.2
通讯作者：
Shoulson,I
中科院分区：
文献类型：
--
作者：
Shoulson,I
The pathogenesis of nigral degeneration underlying Parkinson's disease (PD) has been linked to neurotoxic mechanisms involving oxidation-mediated events.'Deamination of dopamine by age-related increases in monoamine oxidase (MAO) may result in increased fbrmation of hydrogen peroxide and other potentially toxic bypmducts. Depletion of free-radical scavenger enzymes, increased oxidized iron, and heightened lipid peroxidation predispose further to the intrinsic vulnerabilities underlying nigral degeneration. Environmental factors may prompt or hasten nigral degeneration through actions of protoxins, such as l-methyl-Q-phenyl-l, 2, 5, 6-tetrahydmpyridine
