Seafood intake and urine concentrations of total arsenic, dimethylarsinate and arsenobetaine in the US population
Seafood intake and urine concentrations of total arsenic, dimethylarsinate and arsenobetaine in the US population
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DOI：
10.1016/j.envres.2010.10.009
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发表时间：
2011-01-01
影响因子：
8.3
通讯作者：
Guallar, Eliseo
中科院分区：
文献类型：
--
作者：
Navas-Acien, Ana;Francesconi, Kevin A.;Guallar, Eliseo
背景：海鲜是人群中有机砷暴露(砷甜菜碱、砷糖和砷脂)的主要来源。砷的糖和砷脂被代谢成包括二甲基砷(DMA)在内的几种物质。目的：评估2003-2006年国家健康营养与体检调查(NHANES)中海产品摄入量与现场尿砷浓度的关系。方法：对4276名参与者进行为期6年的研究。采用电感耦合等离子体动态反应细胞质谱仪(ICPMS)测定总砷。结果：在过去24小时内，报告海产品的受试者尿中总砷(中位数24.5比7.3微克/L)、二甲基亚胺(6.0微克/L)、砷甜菜碱(10.2比0.9微克/L)和总砷减去白菜碱(11.0比5.5微克/L)浓度较高。报告海鲜与过去一年从未食用过海鲜相比，参与者的得分为2.3(95%可信区间1.9，2.7)。1.4(1.2，1.6)、6.0(4.6，7.8)和1.7(1.4，2.0)倍(p趋势
Background: Seafood is the main source of organic arsenic exposure (arsenobetaine, arsenosugars and arsenolipids) in the population. Arsenosugars and arsenolipids are metabolized to several species including dimethylarsinate (DMA).Objective: Evaluate the association of seafood intake with spot urine arsenic concentrations in the 2003-2006 National Health Nutrition and Examination Survey (NHANES).Methods: We studied 4276 participants >= 6 years. Total arsenic was measured using inductively coupled plasma dynamic reaction cell mass spectrometry (ICPMS). Urine DMA and arsenobetaine were measured by high-performance liquid chromatography coupled with ICPMS.Results: Participants reporting seafood in the past 24-h had higher urine concentrations of total arsenic (median 24.5 vs. 7.3 mu g/L), DMA (6.0 vs. 3.5 mu g/L), arsenobetaine (10.2 vs. 0.9 mu g/L) and total arsenic minus arsenobetaine (11.0 vs. 5.5 mu g/L). Participants reporting seafood >= 2/wk vs. never during the past year had 2.3 (95% confidence interval 1.9, 2.7). 1.4 (1.2, 1.6), 6.0 (4.6, 7.8) and 1.7 (1.4, 2.0) times higher (p-trend