Viral Sequence Analysis from HIV-Infected Mothers and Infants: Molecular Evolution, Diversity, and Risk Factors for Mother-To-Child Transmission
Viral Sequence Analysis from HIV-Infected Mothers and Infants: Molecular Evolution, Diversity, and Risk Factors for Mother-To-Child Transmission
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DOI：
10.1016/j.clp.2010.08.003
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发表时间：
2010-12-01
影响因子：
2.1
通讯作者：
Katzenstein, David A.
中科院分区：
文献类型：
--
作者：
Bulterys, Philip L.;Dalai, Sudeb C.;Katzenstein, David A.
在了解艾滋病毒的发病机制、治疗和传播以及影响母婴传播（MTCT）风险的因素方面已经取得了巨大进展。关于母婴传播背景下艾滋病毒的分子进化和遗传多样性的许多问题仍未得到解答。进一步研究以确定控制哪些变异传播的选择性因素、不同细胞和组织中艾滋病毒的区划如何促进传播，以及宿主免疫、病毒多样性和重组对母婴传播的影响，可能会为新的预防策略和有效艾滋病毒疫苗的开发提供见解。
Great progress has been made in understanding the pathogenesis, treatment, and transmission of HIV and the factors influencing the risk of mother-to-child transmission (MTCT). Many questions regarding the molecular evolution and genetic diversity of HIV in the context of MTCT remain unanswered. Further research to identify the selective factors governing which variants are transmitted, how the compartmentalization of HIV in different cells and tissues contributes to transmission, and the influence of host immunity, viral diversity, and recombination on MTCT may provide insight into new prevention strategies and the development of an effective HIV vaccine.