AS1411 and EpDT3-conjugated silver nanotriangle-mediated photothermal therapy for breast cancer and cancer stem cells.
AS1411 and EpDT3-conjugated silver nanotriangle-mediated photothermal therapy for breast cancer and cancer stem cells.
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DOI：
10.2217/nnm-2021-0257
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发表时间：
2021-11
期刊：
影响因子：
5.5
通讯作者：
Huiquan Yang;Yuyu Cao;Dongdong Li;Fan Li;Jing Ma;Siqi Peng;Peidang Liu
中科院分区：
文献类型：
--
作者：
Huiquan Yang;Yuyu Cao;Dongdong Li;Fan Li;Jing Ma;Siqi Peng;Peidang Liu
Aim: This study aimed to construct AS1411 and EpDT3-conjugated PEGylated silver nanotriangles (AENTs) and assess their ability to target breast cancer and cancer stem cells, as well as the anti tumor and anti metastatic effects of AENTs-mediated photothermal therapy. Materials & methods: AENTs were constructed and characterized. The targeting properties, as well as anti tumor and anti metastatic activities, were evaluated in MDA-MB-231 breast cancer cells, cancer stem cells and breast cancer-bearing mice. Results: AENTs displayed excellent targeting property to breast cancer cells and cancer stem cells. AENTs-mediated photothermal therapy greatly inhibited (>45%) the migration and invasion of breast cancer cells, as well as tumor growth and lung metastasis in the mice. Conclusion: AENTs-mediated photothermal therapy might be an effective strategy for the treatment of breast cancer.
