Changes in pairwise correlations during running reshape global network state in the main olfactory bulb
Changes in pairwise correlations during running reshape global network state in the main olfactory bulb
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DOI：
10.1152/jn.00464.2020
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发表时间：
2021-05-01
影响因子：
2.5
通讯作者：
Padmanabhan, Krishnan
中科院分区：
文献类型：
--
作者：
Chockanathan, Udaysankar;Crosier, Emily J. W.;Padmanabhan, Krishnan
感觉输入的神经编码被假设驻留在由自发活动的持续模式定义的更广阔的空间中。为了了解这种自发活动在嗅觉系统中的结构，我们对清醒小鼠的主要嗅球进行了高密度的神经群记录。我们观察到当动物奔跑时，二尖瓣和丛生(M/T)细胞之间自发活动的成对相关性的变化，这导致了种群熵的增加。令人惊讶的是，仅使用关于神经元的放电率和相关性的假设来描述种群活动的成对最大熵模型，与它们奔跑时相比，在预测动物静止时的全球活动结构方面更好，这意味着更高级别(3，4阶)的相互作用控制着运动期间的种群活动。综上所述，我们发现运动改变了在嗅觉加工的最早阶段形成自发群体活动的功能相互作用，即与鼻上皮中的感觉受体相距一个突触。这些数据表明，可用于感觉表征的编码空间对动物的行为状态做出了适应性反应。值得注意的是，嗅觉系统中自发群体活动的组织和结构限制了气味信息的表征方式。利用二尖瓣和簇状细胞的高密度电生理记录，我们发现跑步增加了自发活动的维度，暗示了运动过程中神经元之间的更高级别的相互作用。因此，在感觉处理的最早阶段，行为可以灵活地改变神经元的活动。
Neural codes for sensory inputs have been hypothesized to reside in a broader space defined by ongoing patterns of spontaneous activity. To understand the structure of this spontaneous activity in the olfactory system, we performed high-density recordings of neural populations in the main olfactory bulb of awake mice. We observed changes in pairwise correlations of spontaneous activity between mitral and tufted (M/T) cells when animals were running, which resulted in an increase in the entropy of the population. Surprisingly, pairwise maximum entropy models that described the population activity using only assumptions about the firing rates and correlations of neurons were better at predicting the global structure of activity when animals were stationary as compared to when they were running, implying that higher order (3rd, 4th order) interactions governed population activity during locomotion. Taken together, we found that locomotion alters the functional interactions that shape spontaneous population activity at the earliest stages of olfactory processing, one synapse away from the sensory receptors in the nasal epithelium. These data suggest that the coding space available for sensory representations responds adaptively to the animal's behavioral state.NEW & NOTEWORTHY The organization and structure of spontaneous population activity in the olfactory system places constraints of how odor information is represented. Using high-density electrophysiological recordings of mitral and tufted cells, we found that running increases the dimensionality of spontaneous activity, implicating higher order interactions among neurons during locomotion. Behavior, thus, flexibly alters neuronal activity at the earliest stages of sensory processing.