Ulapualides C-E Isolated from a Hawaiian Hexabranchus sanguineus Egg Mass.
Ulapualides C-E Isolated from a Hawaiian Hexabranchus sanguineus Egg Mass.
复制标题
Ulapualides C-E 从夏威夷六臂鱼卵团中分离出来。
DOI：
10.1021/acs.jnatprod.6b00896
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发表时间：
2017
影响因子：
5.1
通讯作者：
Williams,PhilipG
中科院分区：
文献类型：
--
作者：
Parrish,StephenM;Yoshida,Wesley;Yang,Baojun;Williams,PhilipG
从六叉血吸虫卵团中分离得到3个新的乌拉帕内酯(3-5)。通过物理和波谱分析，确定了化合物3-5的结构，并与乌拉帕里德A(1)和B(2)进行了比较。乌拉普利C对选定的非小细胞肺癌细胞株(768-0、DU-145、MDAMB-231和A549)表现出亚微摩尔细胞毒性，其中对MDAMB-231细胞的杀伤活性最强(IC500.58IC0.58μM)。乌拉帕里德A(1)和B(2)的效力是3的2到4倍。
Three new ulapualides (3–5) were isolated from egg masses of the nudibranchHexabranchus sanguineus. The structures of3–5were deduced by analyses of physical and spectroscopic data in comparisons with ulapualides A (1) and B (2). Ulapualide C demonstrated submicromolar cytotoxicity against select NCI cell lines (768-0, DU-145, MDA-MB-231, and A549) with the most potent activity against MDA-MB-231 cells (IC500.58 μM). Ulapualides A (1) and B (2) were 2- to 4-fold more potent than3.