Rfam: annotating non-coding RNAs in complete genomes.
Rfam: annotating non-coding RNAs in complete genomes.
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DOI：
10.1093/nar/gki081
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发表时间：
2005-01-01
影响因子：
14.9
通讯作者：
Bateman A
中科院分区：
文献类型：
--
作者：
Griffiths-Jones S;Moxon S;Marshall M;Khanna A;Eddy SR;Bateman A
Rfam是非编码RNA（ncRNA）家族的综合集合，由多序列比对和profile随机上下文无关语法表示。Rfam旨在促进已知序列家族新成员的识别和分类，并在200多个完整的基因组序列中分发ncRNA的注释。这些数据提供了在广泛的分类范围内保护多个ncRNA家族的第一印象。在所有三个生命王国中，少量的大家族是必不可少的，而大量的小家族则是特定于某些分类群的。数据库的最新改进进行了讨论，以及未来的挑战。Rfam可在网站http://www.sanger.ac.uk/Software/Rfam/和http://rfam.wustl.edu/上获得。
Rfam is a comprehensive collection of non-coding RNA (ncRNA) families, represented by multiple sequence alignments and profile stochastic context-free grammars. Rfam aims to facilitate the identification and classification of new members of known sequence families, and distributes annotation of ncRNAs in over 200 complete genome sequences. The data provide the first glimpses of conservation of multiple ncRNA families across a wide taxonomic range. A small number of large families are essential in all three kingdoms of life, with large numbers of smaller families specific to certain taxa. Recent improvements in the database are discussed, together with challenges for the future. Rfam is available on the Web at http://www.sanger.ac.uk/Software/Rfam/ and http://rfam.wustl.edu/.