PRELIMINARY ANALYSIS OF REQUIREMENTS FOR FUSION FROM WITHIN AND FUSION FROM WITHOUT BY NEWCASTLE DISEASE VIRUS
PRELIMINARY ANALYSIS OF REQUIREMENTS FOR FUSION FROM WITHIN AND FUSION FROM WITHOUT BY NEWCASTLE DISEASE VIRUS
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DOI：
10.1073/pnas.64.2.536
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发表时间：
1969-01-01
影响因子：
11.1
通讯作者：
GALLAHER, WR
中科院分区：
文献类型：
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作者：
BRATT, MA;GALLAHER, WR
不同的纽卡斯尔病病毒株诱导细胞融合的能力不同。当以高感染复数给予细胞时，一些菌株在三小时内诱导细胞融合。这种类型的融合显然是由接种物中的病毒颗粒引起的，因为它可以由非感染性病毒诱导，并且不需要蛋白质合成来诱导。它被命名为无融合（FFWO）。其他菌株主要在低感染复数下诱导融合。这种融合仅由感染性病毒诱导，并且需要蛋白质合成来诱导。在这些所需的蛋白质中可能包括病毒抗原，其必须在细胞表面可用以发生融合。这种类型的融合被称为内部融合（FFWI）。
Different strains of Newcastle disease virus vary in their ability to induce cell fusion. When administered to cells at high multiplicities of infection some strains induce cell fusion within three hours. This type of fusion is apparently caused by the virus particles in the inoculum, since it can be induced by noninfectious virus and does not require protein synthesis for induction. It has been designated fusion from without (FFWO). Other strains induce fusion mainly at low multiplicities of infection. This fusion is induced only by infectious virus, and requires protein synthesis for induction. Probably included among these required proteins is a viral antigen which must be available at the cell surface in order for fusion to occur. This type of fusion has been designated fusion from within (FFWI).