High level expression of the anti-retroviral protein APOBEC3G is induced by influenza A virus but does not confer antiviral activity.
High level expression of the anti-retroviral protein APOBEC3G is induced by influenza A virus but does not confer antiviral activity.
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DOI：
10.1186/1742-4690-6-38
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发表时间：
2009-04-16
期刊：
影响因子：
3.3
通讯作者：
Ludwig S
中科院分区：
文献类型：
--
作者：
Pauli EK;Schmolke M;Hofmann H;Ehrhardt C;Flory E;Münk C;Ludwig S
人APOBEC 3G是一种抗逆转录病毒蛋白，其被描述为通过逆转录病毒cDNA的脱氨基作用。然而，有人认为APOBEC蛋白可能通过其他机制发挥抗病毒活性，也可能具有RNA脱氨活性。因此，关于APOBEC蛋白是否也可能对其他RNA病毒具有抗病毒活性的争论正在进行中。甲型流感病毒是单链RNA病毒，能够诱导多种抗病毒基因产物。在寻找针对这些病原体的新型抗病毒基因时，我们检测到感染细胞中APOBEC 3G基因转录的强烈诱导，但未检测到APOBEC 3F基因转录。这种上调似乎是由感染细胞内病毒RNA种类的积累诱导的，并且以NF-κB依赖性但MAP激酶非依赖性方式发生。进一步证明APOBEC表达是对感染的一般IFNβ应答的一部分。然而，尽管APOBEC 3G被强烈诱导，但它不会对甲型流感病毒的繁殖产生负面影响。
Human APOBEC3G is an antiretroviral protein that was described to act via deamination of retroviral cDNA. However, it was suggested that APOBEC proteins might act with antiviral activity by yet other mechanisms and may also possess RNA deamination activity. As a consequence there is an ongoing debate whether APOBEC proteins might also act with antiviral activity on other RNA viruses. Influenza A viruses are single-stranded RNA viruses, capable of inducing a variety of antiviral gene products. In searching for novel antiviral genes against these pathogens, we detected a strong induction of APOBEC3G but not APOBEC3F gene transcription in infected cells. This upregulation appeared to be induced by the accumulation of viral RNA species within the infected cell and occurred in an NF-κB dependent, but MAP kinase independent manner. It further turned out that APOBEC expression is part of a general IFNβ response to infection. However, although strongly induced, APOBEC3G does not negatively affect influenza A virus propagation.
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DOI：
10.1084/jem.20051512
发表时间：
2006-01-23
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Peng G;Lei KJ;Jin W;Greenwell-Wild T;Wahl SM
通讯作者：
Wahl SM
影响因子：
16
作者：
Stopak, K;de Noronha, C;Greene, WC
通讯作者：
Greene, WC
影响因子：
56.9
作者：
Pichlmair, Andreas;Schulz, Oliver;Sousa, Caetano Reis E.
通讯作者：
Sousa, Caetano Reis E.
影响因子：
64.5
作者：
Harris, RS;Bishop, KN;Malim, MH
通讯作者：
Malim, MH
影响因子：
4.8
作者：
Mehle, A;Strack, B;Gabuzda, D
通讯作者：
Gabuzda, D