The nature of behavioural correlates of healthy ageing: a twin study of lifestyle in mid to late life
The nature of behavioural correlates of healthy ageing: a twin study of lifestyle in mid to late life
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DOI：
10.1093/ije/dyt210
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发表时间：
2014-06-01
影响因子：
7.7
通讯作者：
Christensen, Kaare
中科院分区：
文献类型：
--
作者：
McGue, Matt;Skytthe, Axel;Christensen, Kaare
背景随着工业化世界的老龄化，人们对确定促进健康和成功老龄化的可改变的生活方式因素越来越感兴趣。虽然许多与晚年发病率和死亡率相关的行为因素已经被确定，但对于这些因素的个体差异的起源知之甚少。方法通过丹麦双胞胎登记中心确定的12714对双胞胎样本，包括3806对已知合子的两个成员，年龄在40到80岁之间，完成了与衰老相关的六个生活方式因素的自我报告评估：吸烟、饮酒、饮食以及体力、社交和智力活动。结果6个生活方式因素中的每一个因素的遗传度估计值从饮食标准的32%(95%CI：19-42%)到吸烟标准的69%(62-72%)。对这对双胞胎共同养育环境的贡献的生物统计学估计一致很小(千分之一表示6%)。几乎没有证据表明标准化的生物统计学估计因性别或年龄而不同。结论个人构建生活方式可能部分是为了补充和加强潜在的受基因影响的性格和天赋。生活方式因素的可遗传性质意味着，导致老龄化过程的行为和遗传因素在概念上不一定是截然不同的，而是反映了老龄化过程中基因-环境相互作用的复杂性。
Background With the greying of the industrialized world has come increased interest in identifying the modifiable lifestyle factors that promote healthy and successful ageing. Whereas many of the behavioural correlates of late-life morbidity and mortality have been identified, relatively little is known about the origins of individual differences in these factors.Methods A sample of 12 714 twins, including both members of 3806 pairs of known zygosity, ascertained through the Danish Twin Registry and aged 40 to 80 years, completed a self-report assessment of six lifestyle factors associated with ageing: smoking, drinking, diet and physical, social and intellectual activities. Standard biometric methods were used to analyse the twin data and determine the extent to which individual differences in each of the lifestyle factors are heritable.Results For each of the six lifestyle factors, the estimate of heritability ranged from 32% (95% CI: 19-42%) for the diet scale to 69% (62-72%) for the smoking measure. Biometric estimates of the contribution of the twins' common rearing environment were uniformly small (a parts per thousand currency sign6%). There was little evidence that standardized biometric estimates varied by gender or age.Conclusions Individuals likely construct lifestyles in part to complement and reinforce underlying genetically influenced dispositions and talents. The heritable nature of lifestyle factors implies that the behavioural and genetic contributors to ageing processes are not necessarily conceptually distinct but rather reflect the complexity of gene-environment interplay in ageing.