Multiple functions and dynamic activation of MPK-1 extracellular signal-regulated kinase signaling in Caenorhabditis elegans germline development
Multiple functions and dynamic activation of MPK-1 extracellular signal-regulated kinase signaling in Caenorhabditis elegans germline development
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DOI：
10.1534/genetics.107.081356
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发表时间：
2007-12-01
期刊：
影响因子：
3.3
通讯作者：
Schedl, Tim
中科院分区：
文献类型：
--
作者：
Lee, Min-Ho;Ohmachi, Mitsue;Schedl, Tim
生殖系存在的理由是产生卵母细胞和精子，将遗传物质和细胞质成分传递给下一代。为了实现这一目标，许多发展进程必须。执行和协调。ERK是许多信号通路的末端MAP激酶，控制发育的许多方面。在这里，我们提出了一个全面的分析MPK-1 ERK在秀丽隐杆线虫种系发育。MPK-1在四个发育开关中起作用：粗线期进展、卵母细胞减数分裂成熟/排卵、雄性生殖细胞命运特化和促进增殖命运的非必需功能。MPK-1还调节卵子发生过程中细胞生物学的多个方面，包括膜组织和形态发生：性腺管表面粗线期细胞的组织、卵母细胞的组织和分化、卵母细胞生长控制和卵母细胞核迁移。MPK-1激活是时间/空间动态的，大多数过程似乎是通过持续激活控制的。MPK-1 thud不仅可以控制单个过程，也表现在同时期过程的协调和连续过程的整合。MPK-1的动态激活和多种功能的知识为识别负责区域特异性激活的上游信号级联和介导各种过程的下游底物提供了基础。
The raison d'etre of the germline is to produce oocytes and sperm that pass generic material and cytoplasmic constituents to the next generation. To achieve this goal, many developmental processes must. be executed and coordinated. ERK, the terminal MAP kinase of a number of signaling pathways, controls many aspects of development. Here we present a comprehensive analysis of MPK-1 ERK in Caenorhabditis elegans germline development. MPK-1 functions in four developmental switches: progression through pachytene, oocyte meiotic maturation/ovulation, male germ cell fate specification, and a nonessential function of promoting the proliferative fate. MPK-1 also regulates multiple aspects of cell biology during oogenesis, including membrane organization and morphogenesis: organization of pachytene cells on the surface of the gonadal tube, oocyte organization and differentiation, oocyte growth control, and oocyte nuclear migration. MPK-1 activation is temporally/spatially dynamic and most processes appear to be controlled through sustained activation. MPK-1 thud may act not only in the control of individual processes but. also in the coordination of contemporaneous processes and the integration of sequential processes. Knowledge of the dynamic activation and diverse functions of MPK-1 provides the foundation For identification Of upstream signaling cascades responsible for region-specific activation and the downstream substrates that mediate the various processes.