EVALUATION OF OXYGEN DIFFUSION DISTANCES IN HUMAN-BREAST CANCER XENOGRAFTS USING TUMOR-SPECIFIC INVIVO DATA - ROLE OF VARIOUS MECHANISMS IN THE DEVELOPMENT OF TUMOR HYPOXIA
EVALUATION OF OXYGEN DIFFUSION DISTANCES IN HUMAN-BREAST CANCER XENOGRAFTS USING TUMOR-SPECIFIC INVIVO DATA - ROLE OF VARIOUS MECHANISMS IN THE DEVELOPMENT OF TUMOR HYPOXIA
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DOI：
10.1016/0360-3016(88)90313-6
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发表时间：
1988-09-01
影响因子：
7
通讯作者：
VAUPEL, P
中科院分区：
文献类型：
--
作者：
GROEBE, K;VAUPEL, P
考虑到体内特定细胞系的数据，计算了人乳腺癌移植瘤中的氧扩散距离。通过将变量引入描述“标准”情况的一组实验数据，研究了各种肿瘤特异性或系统性机制的影响。有证据表明，辐射抗性可在100微米以上的毛细管间距离处形成。如果毛细血管间距离超过140µm，则微血管的动脉末端已经存在缺氧。“标准”条件下的缺氧明显加重，表现为微血管血流量减少、动静脉分流增加、红细胞流量减少、肿瘤微血管延长、贫血或动脉低氧血症。为这些不同条件计算的低氧组织分数被发现与0-1毫米汞柱的肿瘤组织PO2读数的比例一致。
Oxygen diffusion distances in human breast cancer xenografts are computed considering cell line-specific in vivo data. By introducing variations into a set of experimental data characterizing a "standard" situation, the impacts of various tumor-specific or systemic mechanisms are studied. Evidence is given that radioresistance may develop at intercapillary distances above 100 .mu.m. If intercapillary distances exceed 140 .mu.m, hypoxia is present at the arterial end of microvessels already. Hypoxia evidenced under "standard" conditions is distinctly aggravated by reduction of microvascular blood flow, increased arterio-venous shunt perfusion, reduced red blood cell flux, elongation of tumor microvessels, anemia or arterial hypoxemia. Hypoxic tissue fractions calculated for these various conditions are found to be in accordance with the proportion of tumor tissue PO2-readings at 0-1 mmHg.