Tackling the overdose crisis: The role of safe supply
Tackling the overdose crisis: The role of safe supply
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DOI：
10.1016/j.drugpo.2020.102769
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发表时间：
2020-06-01
影响因子：
4.4
通讯作者：
McNeil, Ryan
中科院分区：
文献类型：
--
作者：
Ivsins, Andrew;Boyd, Jade;McNeil, Ryan
由于芬太尼及其类似物在非法药物供应中的扩散，北美正在经历一场前所未有的药物过量危机。 2018年，美国有67,367人因药物过量死亡，自2016年以来，加拿大已有超过14,700人因药物过量死亡，其中大多数与芬太尼有关。尽管做出了共同努力并取得了一些积极进展，但当前的公共卫生、药物滥用治疗和减少危害干预措施（例如广泛分发纳洛酮和建立监督消费场所）未能迅速减少服药过量死亡人数。鉴于服务方面持续存在的差距和可用选择的限制，迫切需要立即扩大低门槛阿片类药物分配计划。这包括药品级阿片类药物（例如氢吗啡酮）的“标签外”处方，以破坏有毒药物的供应，并使更安全的阿片类药物广泛提供给服用过量致命风险的人。
North America is experiencing an unprecedented overdose crisis driven by the proliferation of fentanyl and its analogues in the illicit drug supply. In 2018 there were 67,367 drug overdose deaths in the United States, and since 2016, there have been more than 14,700 overdose deaths in Canada, with most related to fentanyl. Despite concerted efforts and some positive progress, current public health, substance use treatment, and harm reduction interventions (such as widespread naloxone distribution and implementation of supervised consumption sites) have not been able to rapidly decrease overdose fatalities. In view of the persistent gaps in services and the limitations of available options, immediate scale-up of low-barrier opioid distribution programs are urgently needed. This includes "off-label" prescription of pharmaceutical grade opioids (e.g., hydromorphone) to disrupt the toxic drug supply and make safer opioids widely available to people at high risk of fatal overdose.