Neck circumference as an independent indicator to non-alcoholic fatty liver disease in non-obese men.
Neck circumference as an independent indicator to non-alcoholic fatty liver disease in non-obese men.
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颈围作为非肥胖男性非酒精性脂肪肝的独立指标
DOI：
10.1186/s12986-015-0060-z
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发表时间：
2015
影响因子：
4.5
通讯作者：
Lu Y
中科院分区：
文献类型：
--
作者：
Li Q;Wang N;Han B;Chen Y;Zhu C;Chen Y;Xia F;Cang Z;Zhu C;Chen C;Zhai H;Jiang B;Lin D;Lu Y
为探讨颈围（NC）与非肥胖人群非酒精性脂肪性肝病（NAFLD）的关系，采用2014年华东地区代谢性疾病患病率及危险因素的横断面调查数据。BMI ≥ 18.5 kg/m2且< 25 kg/m2的受试者被视为正常体重。共有2668名18-89岁的参与者被确定用于分析。测量人体测量指标、生化指标、临床特征和腹部超声。结果本研究人群NAFLD总患病率为10.94%，男性患病率高于女性（19.89%vs7.48%，P <0.01）。NAFLD组NC均值明显高于其他组（P <0.01）。NC与BMI、腰围、臀围、收缩压、舒张压、胰岛素、HOMA-IR、甘油三酯和ALT相关，与性别无关。在调整潜在的混杂因素后，在男性而非女性NC水平的最高四分位数中，NAFLD的风险显著更高[比值比2.18，（95%置信区间1.16-4.13）]（趋势P <0.001）。
BackgroundTo investigate the relationship of the neck circumference (NC) with non-alcoholic fatty liver disease (NAFLD) in non-obese Chinese population.MethodsOur data were obtained from a cross-sectional survey on the prevalence of metabolic diseases and risk factors in East China in 2014. Subjects with a BMI ≥ 18.5 kg/m2and < 25 kg/m2were considered normal weight. A total of 2668 participants aged 18–89 were identified for analysis. Anthropometric indices, biochemical parameters, clinical characteristics and abdominal ultrasound were measured. Independent predictors of NAFLD were identified by multiple logistic regressions.ResultsThe overall prevalence of NAFLD was 10.94 % in this study population and men had a higher prevalence than women (19.89 % vs 7.48 %,P <0.01). The mean NC was greater in NAFLD subjects compared with other groups in both genders (P <0.01). NC was correlated to BMI, waist circumference, hip circumference, systolic blood pressure, diastolic blood pressure, insulin, HOMA-IR, triglycerides and ALT, regardless of sex. In the highest quartile of NC levels in men but not in women, the risks were substantially higher for NAFLD [odds ratio 2.18, (95 % confidence interval 1.16–4.13)] (P <0.001 for trend) after adjusting for potential confounding factors.ConclusionNC was an independent indicator for NAFLD in normal weighted men.