Cerebrospinal fluid and serum levels of cytokines and soluble tumor necrosis factor receptor in influenza virus-associated encephalopathy
Cerebrospinal fluid and serum levels of cytokines and soluble tumor necrosis factor receptor in influenza virus-associated encephalopathy
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DOI：
10.1080/0036554021000026986
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发表时间：
2003-01-01
影响因子：
--
通讯作者：
Furukawa, S
中科院分区：
文献类型：
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作者：
Ichiyama, T;Isumi, H;Furukawa, S
本研究测定了15例流感病毒相关脑病患儿脑脊液和血清中白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、可溶性TNF受体1（sTNFR 1）和可溶性E-选择素（sE-selectin）的浓度，以确定细胞因子在发病机制中的作用。酶联免疫吸附法检测细胞因子和sTNFR 1。CSF IL-6、TNF-α和sTNFR 1浓度分别在9、4和4/12名儿童中升高。血清IL-6、TNF-α、sTNFR 1和sE-selectin水平升高分别为10例、2例、5例和7例。4名CSF中TNF-α和sTNFR 1水平升高的儿童有神经系统后遗症。结果表明，不仅在血清中，而且在CSF中的细胞因子在流感病毒相关脑病中起着关键作用，CSF TNF-α和sTNFR 1水平可能对预测神经系统后遗症很重要。
This study determined the concentrations of interieukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), soluble TNF receptor 1 (sTNFR1) and soluble E-selectin (sE-selectin) in cerebrospinal fluid (CSF) and serum from 15 children with influenza virus-associated encephalopathy to determine the role of cytokines in the pathogenesis. Cytokines and sTNFR1 were measured by enzyme-linked immunosorbent assay. The CSF IL-6, TNF-alpha and sTNFR1 concentrations were elevated in 9, 4 and 4 of 12 children, respectively. The serum concentrations of IL-6, TNF-alpha, sTNFR1 and sE-selectin were elevated in 10, 2, 5 and 7 of 13 children, respectively. Four children with elevated TNF-alpha and sTNFR1 levels in the CSF had neurological sequelae. The results suggested that cytokines not only in serum but also in CSF play a pivotal role in influenza virus-associated encephalopathy, and that the CSF TNF-alpha and sTNFR1 levels may be important for predicting neurological sequelae.