Is cell size important?
Is cell size important?
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DOI：
10.4161/cc.6.7.4049
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发表时间：
2007-04-01
期刊：
影响因子：
4.3
通讯作者：
Baserga, Renato
中科院分区：
文献类型：
--
作者：
Baserga, Renato
细胞大小在细胞增殖中起着间接的作用，因为细胞在分裂之前必须加倍。细胞大小主要由控制核糖体RNA合成和核糖体生物发生的RNA聚合酶I的活性决定。1型胰岛素样生长因子受体（IGF-IR）及其对接蛋白胰岛素受体底物-1（IRS-1）以非冗余方式控制约50%的细胞和身体大小。这在小鼠、苍蝇和培养的细胞中肯定是正确的，但在高等哺乳动物中也可能是正确的。有趣的是，胰岛素受体（InR）在控制细胞大小方面不能取代IGF-IR。这可能是由于IGF-IR比InR更有效地转运到细胞核IRS-1，IRS-1然后结合UBF 1，UBF 1是调节RNA pol I活性的蛋白质之一。
Cell size plays an indirect role in cell proliferation, as cells must double in size before dividing. Cell size is largely determined by the activity of RNA polymerase I that controls ribosomal RNA synthesis and ribosome biogenesis. The type 1 insulin-like growth factor receptor (IGF-IR) and its docking protein, insulin receptor substrate-1 (IRS-1) control, in a non-redundant way, about 50% of cell and body size. This is certainly true in mice, flies and cells in culture, but also probably in higher mammals. Interestingly, the insulin receptor (InR) cannot substitute for the IGF-IR in controlling cell size. This is probably due to the fact that the IGF-IR is more effective than the InR in translocationg to the nuclei IRS-1, which then binds UBF1, one of the proteins that regulate RNA pol I activity.