The seroprevalence of hepatitis C virus (HCV) among 559,890 first-time volunteer blood donors in China reflects regional heterogeneity in HCV prevalence and changes in blood donor recruitment models
The seroprevalence of hepatitis C virus (HCV) among 559,890 first-time volunteer blood donors in China reflects regional heterogeneity in HCV prevalence and changes in blood donor recruitment models
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DOI：
10.1111/j.1537-2995.2010.02616.x
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发表时间：
2010-07-01
期刊：
影响因子：
2.9
通讯作者：
Nelson, Kenrad
中科院分区：
文献类型：
--
作者：
Fu, Yongshui;Xia, Wenjie;Nelson, Kenrad
背景技术背景：中国部分地区无偿献血者丙型肝炎病毒抗体（抗-HCV）的流行率有所下降。但我国其他地区无偿献血者中HCV感染情况尚未见报道。本研究的目的是调查2004年至2007年在广州血液中心，中国。研究设计和方法：抗-HCV检测使用两种不同的第三代酶免疫试剂盒的559,890首次志愿献血者中的HCV血清阳性率。结果：在559，890例献血员中，抗-HCV阳性1877例，阳性率为0.335%。抗-HCV阳性率男性显著高于女性（0.37%vs.0.28%，p < 0.001），广东省献血员显著低于外地献血员（0.30%vs.0.40%，p < 0.001）。在1877例抗-HCV阳性献血者中，随机抽取450例进行HCV核酸RT-PCR扩增。其中HCVRNA阳性者270例（60%），HCVRNA阴性者180例（40%）。结论：广东省外献血者中，有相当一部分是来自中国其他地区的外来务工人员，提示中国HCV感染存在地域异质性。本文报告的总体抗-HCV+率是中国献血者中报告的最低率之一，反映了目前招募完全志愿献血者的影响。
BACKGROUND: A decrease in the prevalence of hepatitis C virus antibody (anti-HCV) has been reported among voluntary blood donors in some regions of China. However, the prevalence of HCV among volunteer blood donors in other regions of China has not been reported. The aim of this study was to investigate the seroprevalence of HCV among 559,890 first-time volunteer blood donors recruited during 2004 through 2007 at the Guangzhou Blood Center, China.STUDY DESIGN AND METHODS: Anti-HCV was detected using two different third-generation enzyme immunoassay kits. HCV RNA was detected using reverse transcription-polymerase chain reaction (RTPCR) targeting the 5'-untranslated region of HCV.RESULTS: Among 559,890 donors, 1877 (0.335%) were positive for anti-HCV. The anti-HCV+ rate was significantly higher in males than females (0.37% vs. 0.28%; p < 0.001) and significantly lower among donors living in Guangdong Province than donors who had migrated from other locations (0.30% vs. 0.40%; p < 0.001). Among the 1877 anti-HCV+ donors, 450 were randomly selected for HCV nucleic acid amplification by RT-PCR. Of these, 270 (60%) were HCV RNA+ and 180 (40%) were HCV RNA-.CONCLUSIONS: Many donors from outside Guangdong Province were migrant laborers from other areas in China, suggesting that there is regional heterogenicity in HCV prevalence within China. The overall anti-HCV+ rate reported here is among the lowest reported among blood donors in China reflecting the effect of the current recruitment of exclusively volunteer donors.