DIMETHYLARSINOUS ACID ESTERS OF 1-THIO- AND -SELENOGALACTOSE. A NEW CLASS OF POTENTIAL CARCINOSTATIC AGENTS
DIMETHYLARSINOUS ACID ESTERS OF 1-THIO- AND -SELENOGALACTOSE. A NEW CLASS OF POTENTIAL CARCINOSTATIC AGENTS
复制标题
1-硫代半乳糖和-硒代半乳糖的二甲基胂酸酯。
DOI：
10.1080/03086647808076562
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发表时间：
1978
影响因子：
1.3
通讯作者：
R. Zingaro
中科院分区：
文献类型：
--
作者：
J. R. Daniel;R. Zingaro
本文报道了2，3，4，6-四-O-乙酰基-1-S-二甲基胂基-1-硫代-β-D-吡喃半乳糖（4），1-S-二甲基胂基-1-硫代-β-D-吡喃半乳糖（5）和2，3，4，6-四-O-乙酰基-1-Se-二甲基胂基-1-硒代-β-D-吡喃半乳糖（8）的合成。本文还报道了1-Se-二甲基胂基-1-硒基-β-D-吡喃半乳糖（10）的制备。化合物的特征在于核磁共振，紫外，质谱，以及元素分析。这些化合物的1H NMR谱是不例外的，除了轻微的低场位移的-AsMe 2共振注意到硒衍生物相比，硫化合物。这些化合物的紫外光谱显示出较强的吸收，这可以归因于与As-X（X = S，Se）键相关的n → o跃迁。Se化合物的Δmax相对于类似的S化合物显示出轻微的红移。在所有情况下，这些化合物的质谱显示糖苷配基-XAsMe 2立即损失。其他碎片可以归因于…
Abstract The syntheses of 2,3,4,6-tetra-O-acetyl-1-S-dimethylarsino-1-thio-β-D-galactopyranose (4), 1-S-dimethylarsino-1-thio-β-D-galactopyranose (5), and 2,3,4,6-tetra-O-acetyl-1-Se-dimethylarsino-1-seleno-β-D-galactopyranose (8) are reported. An attempted preparation of 1-Se-dimethylarsino-1-seleno-β-D-galactopyranose (10) is also described. The compounds were characterized by nmr, uv, and mass spectroscopy, as well as elemental analysis. The 1H nmr spectra of these compounds were not exceptional except for the slight down-field shift of the –AsMe2 resonance noted in the selenium derivative as compared to the sulfur compound. Ultraviolet spectra of these compounds showed a relatively intense absorption which can be attributed to an n → o∗ transition associated with the As–X (X = S, Se) bond. The Δmax for the Se compounds show a slight red shift relative to analogous S compounds. The mass spectra of these compounds showed immediate loss of the aglycon, –XAsMe2, in all cases. Other fragments can be ascrib...