BIOPHYSICS. Comment on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase".
BIOPHYSICS. Comment on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase".
复制标题
生物物理学。
DOI：
10.1126/science.aab0095
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发表时间：
2015-08-28
期刊：
影响因子：
--
通讯作者：
Savidge T
中科院分区：
文献类型：
--
作者：
Chen D;Savidge T
Fried等人（Reports，2014年12月19日，第1510页）使用酮类类固醇异构酶作为原型实例证明了生物催化的电场依赖性加速。这些发现没有扩展到水溶液，因为水本身具有太大和太快的场波动而不能提供催化效应。考虑到生理背景，当考虑水的静电相互作用时，电场在催化中起的作用不太重要。
Fried et al. (Reports, 19 December 2014, p. 1510), demonstrate electric field-dependent acceleration of biological catalysis using ketosteroid isomerase as a prototypic example. These findings were not extended to aqueous solution because water by itself has field fluctuations that are too large and fast to provide a catalytic effect. Given physiological context, when water electrostatic interactions are considered, electric fields play a less significant role in the catalysis.