The role of myeloid-derived suppressor cells in gastrointestinal cancer.
The role of myeloid-derived suppressor cells in gastrointestinal cancer.
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骨髓源性抑制细胞在胃肠道癌症中的作用。
DOI：
10.1002/cac2.12156
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Fu L
中科院分区：
文献类型：
--
作者：
Cui C;Lan P;Fu L
胃肠道(GI)癌包括一系列起源于消化系统的恶性肿瘤，这些恶性肿瘤加在一起是全世界被诊断出的最常见的癌症形式。然而，尽管在诊断和治疗方面取得了许多进展，但胃肠道癌症的发病率和死亡率仍在上升。髓系细胞来源的抑制细胞(MDSCs)是未成熟髓系细胞的异质性群体，在某些病理条件下数量增加，如感染和炎症，这种扩张与癌症特别相关。MDSCs主要参与免疫系统的调节，抑制其对肿瘤的反应，有利于肿瘤细胞逃避免疫监视，增加转移和复发。最近的几项研究支持将MDSCs用作癌症患者的预后和预测性生物标志物，并有可能作为一种新的治疗靶点。本文就MDSCs的免疫抑制作用机制作一综述，并对MDSCs参与胃肠道肿瘤进展、预后和治疗的最新研究进展作一综述。这项工作的目的是介绍针对胃肠道肿瘤MDSCs的新治疗方法的发展，希望改善患有这种疾病的患者的预后。胃肠道(GI)癌包括一系列起源于消化系统的恶性肿瘤，这些恶性肿瘤加在一起是全世界被诊断出的最常见的癌症形式。髓系抑制细胞(MDSCs)是未成熟髓系细胞的异质性群体，在某些病理条件下，如感染和炎症，其数量会增加，这种扩张与癌症特别相关。本文就MDSCs的免疫抑制作用机制作一综述，并对MDSCs参与胃肠道肿瘤的进展、预后及治疗的最新研究进展作一综述。
Gastrointestinal (GI) cancer encompasses a range of malignancies that originate in the digestive system, which together represent the most common form of cancer diagnosed worldwide. However, despite numerous advances in both diagnostics and treatment, the incidence and mortality rate of GI cancer are on the rise. Myeloid‐derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that increase in number under certain pathological conditions, such as infection and inflammation, and this expansion is of particular relevance to cancer. MDSCs are heavily involved in the regulation of the immune system and act to dampen its response to tumors, favoring the escape of tumor cells from immunosurveillance and increasing both metastasis and recurrence. Several recent studies have supported the use of MDSCs as a prognostic and predictive biomarker in patients with cancer, and potentially as a novel treatment target. In the present review, the mechanisms underlying the immunosuppressive functions of MDSCs are described, and recent researches concerning the involvement of MDSCs in the progression, prognosis, and therapies of GI cancer are reviewed. The aim of this work was to present the development of novel treatments targeting MDSCs in GI cancer in the hope of improving outcomes for patients with this condition. Gastrointestinal (GI) cancer encompasses a range of malignancies that originate in the digestive system, which together represent the most common form of cancer diagnosed worldwide. Myeloid‐derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that increase in number under certain pathological conditions such as infection and inflammation, and this expansion is of particular relevance to cancer. In the present review, the mechanisms underlying the immunosuppressive functions of MDSCs are described, and recent research concerning the involvement of MDSCs in the progression, prognosis as well as therapies of GI cancer is reviewed.
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DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
影响因子：
--
作者：
Chen MF;Kuan FC;Yen TC;Lu MS;Lin PY;Chung YH;Chen WC;Lee KD
通讯作者：
Lee KD
影响因子：
5.8
作者：
Bunt, Stephanie K.;Mohr, Ashley M.;Bailey, Jennifer M.;Grandgenett, Paul M.;Hollingsworth, Michael A.
通讯作者：
Hollingsworth, Michael A.
影响因子：
5.8
作者：
Daurkin, Irina;Eruslanov, Evgeniy;Kusmartsev, Sergei
通讯作者：
Kusmartsev, Sergei
影响因子：
10.9
作者：
Cannarile MA;Weisser M;Jacob W;Jegg AM;Ries CH;Rüttinger D
通讯作者：
Rüttinger D