Hyperpolarised 3He MRI versus HRCT in COPD and normal volunteers: PHIL trial
Hyperpolarised 3He MRI versus HRCT in COPD and normal volunteers: PHIL trial
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COPD 和正常志愿者中的超极化 3He MRI 与 HRCT：PHIL 试验
DOI：
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发表时间：
2009
影响因子：
24.3
通讯作者：
H. Kauczor
中科院分区：
文献类型：
--
作者：
E. Beek;Anja Dahmen;T. Stavngaard;K. Gast;C. Heussel;F. Krummenauer;J. Schmiedeskamp;J. Wild;L. V. Søgaard;A. Morbach;L. Schreiber;H. Kauczor
本研究的目的是在一项多中心研究中，应用超极化（HP） 3He磁共振成像（MRI）来识别健康志愿者的慢性阻塞性肺疾病（COPD）和α1-抗胰蛋白酶缺乏症（α1-ATD）患者，并将HP 3He MRI结果与高分辨率计算机断层扫描（HRCT）进行比较。HP 3He MRI（表观扩散系数（ADC））和HRCT（平均肺密度（MLD））的定量测量与肺功能测试相关。一项前瞻性三中心研究招募了122名COPD患者（获得性或遗传性）和年龄匹配的不吸烟者。94例受试者完成了所有诊断研究（COPD患者52例，α1-ATD患者13例，健康受试者29例，男性63例，女性31例，中位年龄62岁）。放射科医生的共识评估，盲法其他测试结果，估计非通气肺体积（HP 3He MRI）和病变肺百分比（HRCT）。每个中心的所有数据的定量评估包括ADC （HP 3He MRI）和MLD测量（HRCT），以及与1秒内用力呼气量(FEV1)/用力肺活量（FVC）的相关性，这表明气道阻塞，以及肺对一氧化碳的扩散能力（DL，CO）表明肺泡破坏。以肺功能测试为参考，HP 3He MRI和HRCT的区域分析对正常志愿者的正确分类分别为100%和97%，COPD为42%和69%，α1-ATD为69%和85%。HP 3He MRI与CT的直接比较显示，23%的中度/重度结构异常患者仅有轻度通气缺陷。与肺功能测试相比，ADC在区分COPD患者和健康受试者方面比MLD更有效（p<0.001比0.038）。ADC测量值与DL、CO的相关性优于MLD （r = 0.59对0.29）。超极化3He MRI正确分类COPD患者和正常志愿者。它提供额外的功能信息，而不使用电离辐射，而HRCT提供更好的形态信息。我们展示了使用不同磁共振系统进行多中心研究的可行性。
The aim of the present study was to apply hyperpolarised (HP) 3He magnetic resonance imaging (MRI) to identify patients with chronic obstructive pulmonary disease (COPD) and α1-antitrypsin deficiency (α1-ATD) from healthy volunteers and compare HP 3He MRI findings with high-resolution computed tomography (HRCT) in a multicentre study. Quantitative measurements of HP 3He MRI (apparent diffusion coefficient (ADC)) and HRCT (mean lung density (MLD)) were correlated with pulmonary function tests. A prospective three centre study enrolled 122 subjects with COPD (either acquired or genetic) and age-matched never-smokers. All diagnostic studies were completed in 94 subjects (52 with COPD; 13 with α1-ATD; 29 healthy subjects; 63 males; and 31 females; median age 62 yrs). The consensus assessment of radiologists, blinded for other test results, estimated nonventilated lung volume (HP 3He MRI) and percentage diseased lung (HRCT). Quantitative evaluation of all data for each centre consisted of ADC (HP 3He MRI) and MLD measurements (HRCT), and correlation with forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) indicating airway obstruction, and the diffusing capacity of the lung for carbon monoxide (DL,CO) indicating alveolar destruction. Using lung function tests as a reference, regional analysis of HP 3He MRI and HRCT correctly categorised normal volunteers in 100% and 97%, COPD in 42% and 69% and α1-ATD in 69% and 85% of cases, respectively. Direct comparison of HP 3He MRI and CT revealed 23% of subjects with moderate/severe structural abnormalities had only mild ventilation defects. In comparison with lung function tests, ADC was more effective in separating COPD patients from healthy subjects than MLD (p<0.001 versus 0.038). ADC measurements showed better correlation with DL,CO than MLD (r = 0.59 versus 0.29). Hyperpolarised 3He MRI correctly categorised patients with COPD and normal volunteers. It offers additional functional information, without the use of ionising radiation whereas HRCT gives better morphological information. We showed the feasibility of a multicentre study using different magnetic resonance systems.
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DOI：
10.1164/ajrccm.156.1.9606093
发表时间：
1997-07-01
影响因子：
24.7
作者：
Uppaluri, R;Mitsa, T;McLennan, G
通讯作者：
McLennan, G
影响因子：
19.7
作者：
MacFall, JR;Charles, HC;Ravin, CE
通讯作者：
Ravin, CE
DOI：
10.1513/pats.200603-086ms
发表时间：
2005-01-01
期刊：
Proceedings of the American Thoracic Society
影响因子：
--
作者：
Simon, Brett A;Christensen, Gary E;Reinhardt, Joseph M
通讯作者：
Reinhardt, Joseph M
DOI：
10.1016/j.jtcvs.2005.09.006
发表时间：
2006-01-01
影响因子：
6
作者：
Naunheim, KS;Wood, DE;Deschamps, C
通讯作者：
Deschamps, C