Histological changes of the pancreas in an elderly diabetic patient positive for GAD antibody.
Histological changes of the pancreas in an elderly diabetic patient positive for GAD antibody.
复制标题
一名 GAD 抗体阳性的老年糖尿病患者胰腺的组织学变化。
作者：
S. Murao;K. Hirata;T. Ishida;J. Takahara
我们检查了一位75岁的糖尿病妇女的胰腺组织学变化，她用磺脲类药物治疗了10年，并需要胰岛素治疗10年。在诊断为糖尿病20年后，她的抗谷氨酸脱羧酶抗体（GAD Ab）呈阳性。她的胰腺尸检显示胰岛受损，没有β细胞。这些变化与长期持续的1型糖尿病的变化难以区分，并且没有发现胰岛炎。该病例表明，GAD Ab阳性的糖尿病患者，即使口服降糖药有效，也可能在长时间内发生完全的β细胞破坏。
We examined the histological changes of the pancreas in a 75-year-old diabetic woman who was treated with sulphonylurea for 10 years and required insulin treatment for the subsequant 10 years. She was positive for antiglutamic acid decarboxylase antibody (GAD Ab) 20 years after the diagnosis of diabetes. Her autopsied pancreas revealed disfigured islets and no beta cells. These changes were indistinguishable from those of the long-sustained type 1 diabetes mellitus, and insulitis was not found. This case suggests that diabetic patients positive for the GAD Ab, even if oral hypoglycemic agents are effective, may develop complete beta cell destruction over a long period.