Atom-Economical Synthesisof Cyclic Imides
Atom-Economical Synthesisof Cyclic Imides
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DOI：
10.1055/s-0030-1260779
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发表时间：
2011-07
期刊：
影响因子：
2
通讯作者：
S. Muthaiah;S. Hong
中科院分区：
文献类型：
--
作者：
S. Muthaiah;S. Hong
以简单的二元醇和伯胺为原料，在原位生成的Ru催化体系中一步合成了环酰亚胺。所开发的方法是原子经济的，操作简单，用于合成琥珀酰亚胺、邻苯二甲酰亚胺和戊二酰亚胺，这些都是天然产品和药物的重要组成部分。并对环酰亚胺的其他合成方法进行了综述。
Cyclic imides were synthesized from simple diols with primary amines in a single step using an in situ generated ruthenium catalytic system. The developed methodology is atom economical and operatively simple for the syntheses of succinimides, phthalimides, and glutarimides, which are important building blocks in natural products and drugs. Other recent approaches for the cyclic imide synthesis were also reviewed.