Prostaglandin E2 receptor antagonist (SC-19220) treatment restores the balance to bone marrow myelopoiesis after burn sepsis.
Prostaglandin E2 receptor antagonist (SC-19220) treatment restores the balance to bone marrow myelopoiesis after burn sepsis.
复制标题
前列腺素 E2 受体拮抗剂 (SC-19220) 治疗可恢复烧伤脓毒症后骨髓造血的平衡。
DOI：
10.1097/00005373-200005000-00005
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Shankar,R
中科院分区：
文献类型：
--
作者：
Santangelo,S;Shoup,M;Gamelli,RL;Shankar,R
BackgroundAlthough prostaglandin E 2 (PGE 2) has been shown to be immunosuppressive, its role in the development of specific bone marrow myeloid lineages after thermal injury and sepsis has yet to be elucidated. The purpose of this study was to demonstrate that alterations in bone marrow progenitor proliferation favoring monocytopoiesis in burn sepsis can be restored by blocking the cellular interactions of PGE 2.MethodsA murine model of burn sepsis with and without treatment with SC-19220, a PGE 2 receptor antagonist, was used to determine peripheral monocyte and neutrophil counts as well as the colony forming potential of colony-stimulating factor responsive bone marrow progenitors.ResultsBurn sepsis augmented the growth of the early colony-forming unit granulocyte-macrophage and monocyte progenitors and the number of circulating monocytes, whereas granulocyte progenitors and circulating neutrophils demonstrated an opposite response. Treatment with SC-19220 nearly reversed these alterations.ConclusionThese data indicate that abrogating PGE 2’s actions during burn sepsis can restore the balance in bone marrow granulocyte and monocyte production, further consolidating the pivotal role PGE 2 plays in the pathogenesis of burn sepsis.
