Coxiella burnetii shedding and environmental contamination at lambing in two highly naturally-infected dairy sheep flocks after vaccination
Coxiella burnetii shedding and environmental contamination at lambing in two highly naturally-infected dairy sheep flocks after vaccination
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DOI：
10.1016/j.rvsc.2010.11.014
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发表时间：
2011-12-01
影响因子：
2.4
通讯作者：
Garcia-Perez, A. L.
中科院分区：
文献类型：
--
作者：
Astobiza, I.;Barandika, J. F.;Garcia-Perez, A. L.
2007/08赛季，在两个自然感染的奶牛羊群中证实了贝氏柯克斯体导致的流产。C的比例。流产母羊或产羔母羊的阴道粘液中贝氏体脱落物和细菌负荷较高，群内血清阳性率也较高。在下一个繁殖季节（2008/09年）之前，75%的母羊和50%的后备羔羊接种疫苗（Coxevac，CEVA Sante Animale），其余作为未处理对照。与前一年的结果相比，当流产爆发时，流产的百分比，脱落的数量和母羊排泄的细菌负荷都大大减少。然而，两个羊群中未接种疫苗的一岁幼畜的血清转化和产羔时在绵羊饲养场采集的生物气溶胶中存在贝氏梭菌DNA表明感染仍然活跃。在接种组和对照组之间，未观察到C的比例存在差异。贝氏菌脱落。这些结果表明，在严重感染的鸡群中接种疫苗的最佳结果可能不会在短期内获得。(C)2010爱思唯尔有限公司保留所有权利。
Abortion due to Coxiella burnetii was confirmed in the 2007/08 season in two naturally-infected dairy sheep flocks. Proportion of C. burnetii shedders and bacterial loads in vaginal mucus were high among aborted or lambed ewes, as was within-flock seroprevalence. Before the next reproductive season (2008/09) 75% of ewes and 50% of replacement lambs were vaccinated (Coxevac, CEVA Sante Animale) keeping the remaining as untreated controls. Compared with the previous year results when abortion outbreak started, a great reduction in the percentage of abortions, in the number of shedders and in the bacterial burden excreted by the ewes was found in both flocks. However, seroconversion in non-vaccinated yearlings from both flocks and the presence of C burnetii DNA in bioaerosols taken at sheep premises at lambing indicated that infection was still active. No differences were observed between vaccinated and control groups in terms of proportion of C. burnetii shedders. These results suggest that optimal results of vaccination in heavily infected flocks may not be obtained in a short-term period. (C) 2010 Elsevier Ltd. All rights reserved.