Blood glucose concentrations are reduced in children born small for gestational age (SGA), and thyroid-stimulating hormone levels are increased in SGA with blunted postnatal catch-up growth
Blood glucose concentrations are reduced in children born small for gestational age (SGA), and thyroid-stimulating hormone levels are increased in SGA with blunted postnatal catch-up growth
复制标题
DOI：
10.1210/jc.2002-021882
复制
发表时间：
2003-06-01
影响因子：
5.8
通讯作者：
Germani, D
中科院分区：
文献类型：
--
作者：
Cianfarani, S;Maiorana, A;Germani, D
胎儿生长受限与成年后发生胰岛素抵抗和2型糖尿病的风险增加有关。此外，10-20%出生时小于胎龄（SGA）的儿童不能达到正常的最终身高。本研究的目的是探讨SGA儿童的胰岛素敏感性和内分泌状况，并将其与适胎龄儿（AGA）进行比较。此外，在SGA组中，我们旨在将出生后生长与人体测量、生化和内分泌参数联系起来。研究了82例SGA患儿（平均年龄8.6+/-3.5岁）和53例short-AGA患儿（平均年龄9.3+/-3.3岁）。对26例SGA和26例short-AGA受试者进行病例对照研究。对于每个SGA受试者，我们选择了一名身高较矮的aga儿童，其性别、年龄（1岁以内）、青春期状态、体重指数（0.5 kg/m(2)以内）和身高（0.25 z-score以内）相匹配。对儿童身高进行校正，并将SGA儿童分为2组：追赶生长组（CG）（校正后身高至少为0 z-score的儿童）；非cg组（NCG组）（校正身高小于0 z-score的受试者）。SGA组与short-AGA组相比，空腹胰岛素、空腹葡萄糖/胰岛素比值、胰岛素抵抗稳态评估模型、稳态评估模型- β细胞值均无显著差异。SGA儿童血糖水平显著降低(4.4+/-0.6 vs. 4.9+/-0.6 mM， P
Fetal growth restriction is associated with an increased risk of developing insulin resistance and type 2 diabetes in adulthood. In addition, 10-20% of children born small for gestational age (SGA) do not achieve a normal final height. The purpose of this study was to investigate insulin sensitivity and endocrine status in SGA children, compared with that in children born appropriate for gestational age (AGA). Furthermore, within the SGA group, we aimed to relate postnatal growth to anthropometric, biochemical, and endocrine parameters. Eighty-two SGA children (with a mean age of 8.6+/-3.5 yr) and 53 short-AGA children (with a mean age of 9.3+/-3.3 yr) were studied. A case-control study was carried out in 26 SGA and 26 short-AGA subjects. For each SGA subject, we selected a short-AGA child matched for sex, age (within 1 yr), pubertal status, body mass index (within 0.5 kg/m(2)), and height (within 0.25 z-score). Children's statures were corrected for their midparental height, and SGA children were subdivided into 2 groups: catch-up growth (CG) group (children with corrected height with at least 0 z-score); and non-CG (NCG) group (subjects with corrected height with less than 0 z-score). Comparing SGA with short-AGA subjects, no significant differences in fasting insulin, fasting glucose/insulin ratio, homeostasis assessment model for insulin resistance, and homeostasis assessment model-beta-cell values were observed. SGA children showed significantly reduced levels of glucose (4.4+/-0.6 vs. 4.9+/-0.6 mM, P