MULTIPLE-SCLEROSIS AND AUTOIMMUNE DISEASES
MULTIPLE-SCLEROSIS AND AUTOIMMUNE DISEASES
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DOI：
10.1111/j.1445-5994.1972.tb03071.x
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发表时间：
1972-01-01
期刊：
影响因子：
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通讯作者：
EBELING, P
中科院分区：
文献类型：
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作者：
BAKER, HWG;BALLA, JI;EBELING, P
疾病关联为病因不明的疾病提供有用的病原学线索；这尤其适用于往往同时发生在个体和相关家庭成员中的自身免疫疾病。对1955年至1970年间一家大城市医院收治的326例多发性硬化症患者的病例记录进行调查，发现9例患者同时患有多发性硬化症和假定的自身免疫性疾病。自身免疫性疾病累及甲状腺4例，胃2例，肾上腺1例，类风湿关节炎2例，寻常性天疱疮1例。这些关联与多发性硬化症自身免疫发病机制的概念相关，但基于这些疾病在澳大利亚的不确定患病率以及此类研究固有的确定错误，有保留意见。
Disease associations provide useful aetiological clues in relation to diseases of unknown causation; this holds particularly for auto‐immune disorders which tend to occur together in individuals and in related family members. Nine patients suffering from both multiple sclerosis and presumed auto‐immune disorder were found from a survey of case records of 326 patients with multiple sclerosis admitted to a large city hospital between 1955 and 1970. There was autoimmune disease affecting the thyroid gland in four cases, the stomach in two and the adrenal gland in one, and there were two cases of rheumatoid arthritis and one of pemphigus vulgaris. Such associations are relevant to the concept of an auto‐immune pathogenesis for multiple sclerosis, but with reservations based on the uncertain prevalence of these diseases in Australia and the ascertainment errors inherent in this type of study.