Extrapyramidal motor abnormalities associated with late-life psychosis.
Extrapyramidal motor abnormalities associated with late-life psychosis.
复制标题
与晚年精神病相关的锥体外系运动异常。
DOI：
10.1093/schbul/19.4.747
复制
发表时间：
1993
影响因子：
6.6
通讯作者：
Harris,MJ
中科院分区：
文献类型：
--
作者：
Caligiuri,MP;Lohr,JB;Panton,D;Harris,MJ
对精神分裂症患者锥体外系运动功能的研究有助于我们理解与抗精神病药物相关的现象学和治疗结果。越来越多的文献表明，与精神分裂症相关的锥体外系运动异常可能与精神分裂症的病理生理机制有关。同样，已有文献证明，锥体外系可能参与阿尔茨海默病(AD)患者的运动异常。本研究旨在探讨精神分裂症和阿尔茨海默病患者的运动功能。对13例未服用抗精神病药的精神分裂症患者、13例阿尔茨海默病精神病患者和26例年龄相仿的对照组进行了强直、震颤和运动迟缓的定量检测。精神分裂症和阿尔茨海默病患者的震颤和僵硬评分均显著高于正常对照组。这项对精神分裂症和AD患者合并精神病的对比研究表明，精神病患者患痴呆症的效果是延长运动时间，而在没有痴呆症的情况下，异常的帕金森氏姿势震颤往往与精神病有关。
Studies of extrapyramidal motor function in patients with schizophrenia have contributed to our understanding of the phenomenology and therapeutic outcome associated with neuroleptics. An increasing body of literature suggests that extrapyramidal motor abnormalities associated with schizophrenia may be linked to the pathophysiological mechanisms responsible for schizophrenia. Similarly, it has been documented that the extrapyramidal system may be involved in motor abnormalities in patients with Alzheimer's disease (AD). The present study was under-taken to examine motor function in schizophrenia and AD patients with psychosis. Quantitative instrumental procedures were used to examine rigidity, tremor, and bradykinesia in 13 neuroleptic-naive patients with schizophrenia, 13 AD patients with psychosis, and 26 age-comparable controls. Both schizophrenia and AD patients had significantly higher tremor and rigidity scores than did normal subjects. This comparative study of schizophrenia and AD patients with psychosis suggests that the effect of dementia in patients with psychosis is to prolong movement time, whereas abnormal parkinsonian postural tremor tends to be associated with psychosis in the absence of dementia.