Relationships and host range of human, canine, simian and porcine isolates of simian virus 5 (parainfluenza virus 5)
Relationships and host range of human, canine, simian and porcine isolates of simian virus 5 (parainfluenza virus 5)
复制标题
DOI：
10.1099/vir.0.80200-0
复制
发表时间：
2004-10-01
影响因子：
3.8
通讯作者：
Randall, RE
中科院分区：
文献类型：
--
作者：
Chatziandreou, N;Stock, N;Randall, RE
对13个人、犬、猪和猿猴分离的猿猴病毒5型（SV 5）的V/P和F基因的序列比较显示，尽管这些病毒分离了30多年，并且来自世界各国，但在核苷酸和氨基酸水平上都惊人地缺乏序列变异（0-3%）。此外，没有明确区分氨基酸或核苷酸之间的差异，完全相关的物种，他们被隔离的隔离。此外，没有证据表明病毒通过靶向STAT 1降解来阻断干扰素信号传导的能力仅限于分离它们的物种。与原始W3 A和WR猴分离株相比，所有分离株在F蛋白中具有延长的胞质尾区。对20世纪80年代从伦敦分离的人类骨髓细胞中分离出的病毒进行的序列分析显示，虽然它们之间的关系比其他分离株更密切，但它们都具有识别差异，这表明它们是独立的分离株。因此，这些结果支持了先前的数据，表明SV 5可以持续感染人类，尽管SV 5与任何人类疾病的关系仍然存在高度争议。鉴于SV 5已多次从不同物种中分离出来，因此提出猴病毒5这一术语不合适，并建议将该病毒重命名为副流感病毒。病毒5.
Sequence comparison of the V/P and F genes of 13 human, canine, porcine and simian isolates of simian virus 5 (SV5) revealed a surprising lack of sequence variation at both the nucleotide and amino acid levels (0-3%), even though the viruses were isolated over 30 years and originated from countries around the world. Furthermore, there were no clear distinguishing amino acid or nucleotide differences among the isolates that correlated completely with the species from which they were isolated. In addition, there was no evidence that the ability of the viruses to block interferon signalling by targeting STAT1 for degradation was confined to the species from which they were isolated. All isolates had an extended cytoplasmic tail in the F protein, compared with the original W3A and WR monkey isolates. Sequence analysis of viruses that were derived from human bone-marrow cells isolated in London in the 1980s revealed that, whilst they were related more closely to one another than to the other isolates, they all had identifying differences, suggesting that they were independent isolates. These results therefore support previous data suggesting that SV5 can infect humans persistently, although the relationship of SV5 to any human disease remains highly contentious. Given that SV5 has been isolated on multiple occasions from different species, it is proposed that the term simian virus 5 is inappropriate and suggested that the virus should be renamed parainfluenza. virus 5.