ACTIVATION OF A MEMBER OF THE STEROID-HORMONE RECEPTOR SUPERFAMILY BY PEROXISOME PROLIFERATORS
ACTIVATION OF A MEMBER OF THE STEROID-HORMONE RECEPTOR SUPERFAMILY BY PEROXISOME PROLIFERATORS
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DOI：
10.1038/347645a0
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发表时间：
1990-10-18
期刊：
影响因子：
64.8
通讯作者：
GREEN, S
中科院分区：
文献类型：
--
作者：
ISSEMANN, I;GREEN, S
我们克隆了配体激活转录因子的类固醇激素受体超家族的一个成员。受体同源物被多种啮齿类动物肝癌原激活，导致过氧化物酶体增殖。过氧化物酶体增殖物激活受体的鉴定应有助于阐明这些肝癌物质降血脂作用的机制，并有助于评估其对人类的潜在致癌风险。
We have cloned a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. The receptor homologue is activated by a diverse class of rodent hepatocarcinogens that causes proliferation of peroxisomes. Identification of a peroxisome proliferator-activated receptor should help elucidate the mechanism of the hypolipidaemic effect of these hepatocarcinogens and aid evaluation of their potential carcinogenic risk to man.