Highly efficient cavitation-enhanced heating with dual-frequency ultrasound exposure in high-intensity focused ultrasound treatment
Highly efficient cavitation-enhanced heating with dual-frequency ultrasound exposure in high-intensity focused ultrasound treatment
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DOI：
10.7567/jjap.53.07kf11
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发表时间：
2014-06
影响因子：
1.5
通讯作者：
H. Sasaki;Jun Yasuda;R. Takagi;T. Miyashita;K. Goto;S. Yoshizawa;S. Umemura
中科院分区：
文献类型：
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作者：
H. Sasaki;Jun Yasuda;R. Takagi;T. Miyashita;K. Goto;S. Yoshizawa;S. Umemura
高强度聚焦超声（HIFU）治疗是一种非侵入性治疗恶性肿瘤以及良性肿瘤。在这种方法中，超声波在体外产生并聚焦到目标组织。因此，对患者的身体和精神压力最小。HIFU治疗的缺点是由于单次暴露的治疗体积小，因此对于大肿瘤的治疗时间长。利用空化气泡增强超声的加热效果可以解决这一问题。它们是由高强度的超声波照射产生的，可以高效地将声能转化为热量。在这项研究中，我们结合了“双频超声曝光”的空化气泡云的有效生成和扩展，和“多触发HIFU”的有效增强超声加热。结果表明，新提出的组合方法比传统的触发HIFU方法更有效。
High-intensity focused ultrasound (HIFU) treatment is a noninvasive therapy for malignant as well as benign tumors. In this method, the ultrasound is generated outside the body and focused to the target tissue. Therefore, physical and mental stresses on the patient are minimal. A drawback of HIFU therapy is the long treatment time for a large tumor owing to a small therapeutic volume by a single exposure. Enhancing the heating effect of ultrasound by cavitation bubbles may solve this problem. They are generated by high-intensity ultrasound exposure and can convert the acoustic energy into heat at a high efficiency. In this study, we combined “dual-frequency ultrasound exposure” for the efficient generation and expansion of a cavitation bubble cloud, and “multiple-triggered HIFU” for the efficient enhancement of ultrasonic heating. The result suggests that the newly proposed combined method is more efficient than the conventional triggered HIFU method.