Renovation of Optically Active Phenanthrolines as Powerful Chiral Ligands for Versatile Asymmetric Metal Catalysis
Renovation of Optically Active Phenanthrolines as Powerful Chiral Ligands for Versatile Asymmetric Metal Catalysis
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DOI：
10.1002/tcr.201600078
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发表时间：
2016-12-01
期刊：
影响因子：
6.6
通讯作者：
Nishiyama, Hisao
中科院分区：
文献类型：
--
作者：
Naganawa, Yuki;Nishiyama, Hisao
在不对称合成领域，几十年来，新的手性配体的开发一直被认为是一个有吸引力的挑战。新的手性配体通常会对合成方案产生重大影响。在这种背景下，我们目前感兴趣的应用1，10-菲咯啉（phen）作为一个全新的类别的手性配体。为了解决这个问题，我们设计了一种手性phen配体，它提供了phen部分的N，N，O-三齿配位和一个额外的酚羟基。由于phen与各种离子具有较强的配位能力，我们的手性phen配体将作为一种“特权”手性配体应用于广泛的金属催化剂和新反应中。本文综述了手性邻菲咯啉配体在各种金属催化中的应用结果。
In the field of asymmetric synthesis, the development of new chiral ligands has been regarded as an attractive challenge for decades. Novel chiral ligands can often have a great impact on synthetic protocols. In this context, we are currently interested in the application of 1,10-phenanthroline (phen) as an entirely new class of chiral ligand. To handle this issue, we designed a chiral phen ligand that provides the N,N,O-tridentate coordination of the phen moiety and an additional phenolic hydroxyl group. As phen possesses greater coordination ability with various ions, our chiral phen ligand would be valuable as one of the "privileged" chiral ligands applied to a broad range of metal catalysts and new reactions. This account summarizes the results of the application of the chiral phen ligand to various kinds of metal catalysis.