Interplay between tumor microenvironment and partial EMT as the driver of tumor progression.
Interplay between tumor microenvironment and partial EMT as the driver of tumor progression.
复制标题
DOI：
10.1016/j.isci.2021.102113
复制
发表时间：
2021-02-19
期刊：
影响因子：
5.8
通讯作者：
Sant S
中科院分区：
文献类型：
--
作者：
Aggarwal V;Montoya CA;Donnenberg VS;Sant S
上皮-间质转化（EMT）是一种进化保守现象，已被广泛研究，以解决癌症亚型治疗方案中未解决的可变治疗反应。EMT长期以来被设想为调节肿瘤发生期间的肿瘤侵袭、迁移和治疗抗性。然而，最近已经强调EMT涉及中间部分EMT（pEMT）表型，其由上皮标记物的不完全损失和间充质标记物的不完全获得定义。已经进一步强调，pEMT转变涉及在pEMT谱的任一侧上的中间杂化态的谱。新出现的证据强调了在pEMT表型的获得中肿瘤细胞和周围微环境之间的双向串扰。虽然许多工作仍在进行中，以获得机制的见解pEMT表型的调节，很明显，pEMT在肿瘤的侵袭，侵袭，迁移和转移沿着治疗耐药性中起着关键作用。在这篇综述中，我们专注于肿瘤内在因子和肿瘤微环境在驱动pEMT中的重要作用，并强调工程控制的微环境有助于提供pEMT生物学的机制见解。我们还讨论了pEMT在调节肿瘤进展的标志，即细胞周期调节，集体迁移和治疗耐药性方面的意义。尽管pEMT领域不断发展，但目前的进展和势头有望揭示新的治疗靶点，以在早期阶段阻止肿瘤进展，并解决在许多癌症类型中观察到的复杂治疗耐药性。部分EMT表型驱动肿瘤进展的关键标志肿瘤微环境通过细胞信号传导途径在pEMT表型中的作用研究pEMT表型的3D体外模型工程理解pEMT表型的机会和挑战细胞生物学的功能方面;癌症;生物工程;组织工程
Epithelial-to-mesenchymal transition (EMT), an evolutionary conserved phenomenon, has been extensively studied to address the unresolved variable treatment response across therapeutic regimes in cancer subtypes. EMT has long been envisaged to regulate tumor invasion, migration, and therapeutic resistance during tumorigenesis. However, recently it has been highlighted that EMT involves an intermediate partial EMT (pEMT) phenotype, defined by incomplete loss of epithelial markers and incomplete gain of mesenchymal markers. It has been further emphasized that pEMT transition involves a spectrum of intermediate hybrid states on either side of pEMT spectrum. Emerging evidence underlines bi-directional crosstalk between tumor cells and surrounding microenvironment in acquisition of pEMT phenotype. Although much work is still ongoing to gain mechanistic insights into regulation of pEMT phenotype, it is evident that pEMT plays a critical role in tumor aggressiveness, invasion, migration, and metastasis along with therapeutic resistance. In this review, we focus on important role of tumor-intrinsic factors and tumor microenvironment in driving pEMT and emphasize that engineered controlled microenvironments are instrumental to provide mechanistic insights into pEMT biology. We also discuss the significance of pEMT in regulating hallmarks of tumor progression i.e. cell cycle regulation, collective migration, and therapeutic resistance. Although constantly evolving, current progress and momentum in the pEMT field holds promise to unravel new therapeutic targets to halt tumor progression at early stages as well as tackle the complex therapeutic resistance observed across many cancer types. Partial EMT phenotype drives key hallmarks of tumor progression Role of tumor microenvironment in pEMT phenotype via cellular signaling pathways Engineering 3D in vitro models to study pEMT phenotype Opportunities and challenges in understanding pEMT phenotype Functional aspects of cell biology; cancer; bioengineering; tissue engineering
登录
查看更多内容
EMT亚型影响上皮可塑性和细胞迁移模式。
影响因子：
11.8
作者：
Aiello NM;Maddipati R;Norgard RJ;Balli D;Li J;Yuan S;Yamazoe T;Black T;Sahmoud A;Furth EE;Bar-Sagi D;Stanger BZ
通讯作者：
Stanger BZ
影响因子：
3.7
作者：
Dmello C;Sawant S;Alam H;Gangadaran P;Mogre S;Tiwari R;D'Souza Z;Narkar M;Thorat R;Patil K;Chaukar D;Kane S;Vaidya M
通讯作者：
Vaidya M
DOI：
10.1186/s13058-016-0740-2
发表时间：
2016-08-11
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Bussard KM;Mutkus L;Stumpf K;Gomez-Manzano C;Marini FC
通讯作者：
Marini FC
影响因子：
11.2
作者：
Bocci, Federico;Jolly, Mohit Kumar;Onuchic, Jose Nelson
通讯作者：
Onuchic, Jose Nelson
影响因子：
14.5
作者：
da Silva-Diz, Victoria;Lorenzo-Sanz, Laura;Munoz, Purification
通讯作者：
Munoz, Purification