Differential effects of M1 muscarinic receptor blockade and nicotinic receptor blockade in the dorsomedial striatum on response reversal learning.
Differential effects of M1 muscarinic receptor blockade and nicotinic receptor blockade in the dorsomedial striatum on response reversal learning.
复制标题
背内侧纹状体 M1 毒蕈碱受体阻断和烟碱受体阻断对反应逆转学习的不同影响。
DOI：
10.1016/j.bbr.2004.02.011
复制
发表时间：
2004
影响因子：
2.7
通讯作者：
Ragozzino,MichaelE
中科院分区：
文献类型：
--
作者：
Tzavos,Arianna;Jih,Jane;Ragozzino,MichaelE
目前的研究确定了在背内侧纹状体阻断m1样毒蕈碱受体或烟碱能受体是否会影响反应辨别的习得或反转学习。测试是在一个经过修改的交叉迷宫中进行的，跨越两个连续的阶段。在获取阶段，老鼠学会向左或向右转。在反向学习阶段，大鼠学会了在获取过程中按照要求向相反的方向转弯。实验1研究了m1样毒蕈碱受体拮抗剂吡仑西平对背内侧纹状体习得和逆转学习的影响。实验2研究烟碱能拮抗剂甲美胺对背内侧纹状体习得和反转学习的影响。双侧注射10μg的吡仑西平选择性地损害了反转学习，而不是1μg。对误差的分析表明，吡仑西平治疗并没有损害最初的反应选择，但增加了初始反应选择后的回归。双侧注射6或18μg的甲美胺不影响习得或反转学习。结果表明，在背内侧纹状体中，m1毒蕈碱类胆碱能受体的激活，而不是烟碱类胆碱能受体的激活，对于促进反应模式的灵活转变是重要的。
The present studies determined whether blockade of M1-like muscarinic or nicotinic cholinergic receptors in the dorsomedial striatum affects acquisition or reversal learning of a response discrimination. Testing occurred in a modified cross-maze across two consecutive sessions. In the acquisition phase, a rat learned to turn to the left or to the right. In the reversal learning phase, a rat learned to turn in the opposite direction as required during acquisition. Experiment 1 investigated the effects of the M1-like muscarinic receptor antagonist, pirenzepine infused into the dorsomedial striatum on acquisition and reversal learning. Experiment 2 examined the effects of the nicotinic cholinergic antagonist, mecamylamine injected into the dorsomedial striatum on acquisition and reversal learning. Bilateral injections of pirenzepine at 10μg, but not 1μg, selectively impaired reversal learning. Analysis of the errors indicated that pirenzepine treatment did not impair the initial shift, but increased reversions back to the original response choice following the initial shift. Bilateral injections of mecamylamine, 6 or 18μg, did not affect acquisition or reversal learning. The results suggest that activation of M1muscarinic cholinergic receptors, but not nicotinic cholinergic receptors, in the dorsomedial striatum is important for facilitating the flexible shifting of response patterns.