Comparison of two oral electrolyte solutions and route of administration on the abomasal emptying rate of Holstein-Friesian calves.
Comparison of two oral electrolyte solutions and route of administration on the abomasal emptying rate of Holstein-Friesian calves.
复制标题
两种口服电解质溶液及给药途径对荷斯坦-弗里斯兰犊牛皱胃排空率影响的比较。
DOI：
--
复制
发表时间：
2006
影响因子：
2.6
通讯作者：
P. Constable
中科院分区：
文献类型：
--
作者：
M. Nouri;P. Constable
腹泻的脱水小牛常规通过哺乳或食管插管给予口服电解质溶液（OES）。与补液治疗相关的一个重要问题是OES输送至小肠的速率。人们普遍认为OES的葡萄糖含量不会影响复苏速度，并且通过食管插管给予的液体提供了与通过吸吮获得的相似的复苏反应。本研究的目的是比较哺乳含高或低葡萄糖浓度OES的小牛与通过哺乳或食管插管给予高糖OES的小牛的皱胃排空率。以随机顺序对7头雄性荷斯坦-弗里斯兰小牛进行以下处理：通过哺乳或食管插管给予2 L市售高葡萄糖OES（[葡萄糖] = 405 mM），或通过哺乳给予2 L市售低葡萄糖OES（[葡萄糖] = 56 mM）。通过对乙酰氨基酚吸收、超声检查和葡萄糖吸收测定皱胃排空率。高糖OES迅速增加血浆葡萄糖浓度后，哺乳，但产生的皱胃排空速度慢于低糖OES。经食道插管高葡萄糖OES产生相同的初始变化，在真胃体积没有吸吮，但延迟的OES交付到小肠的速度。我们的研究结果表明，低葡萄糖OES提供了最快的皱胃排空率和血浆容量扩张，而高葡萄糖OES提供了最合适的口服溶液治疗低血糖小牛。
Dehydrated calves with diarrhea are routinely given an oral electrolyte solution (OES) by suckling or esophageal intubation. An important issue related to rehydration therapy is the rate of OES delivery to the small intestine. It is widely assumed that the glucose content of the OES does not impact the speed of resuscitation and that fluid administered by esophageal intubation provides a similar resuscitative response to that obtained by suckling. The aims of this study were to compare the abomasal emptying rate in calves suckling an OES containing a high or low glucose concentration and in calves administered a high-glucose OES by suckling or esophageal intubation. Seven male Holstein-Friesian calves were given the following treatments in random order: 2 L of a commercially available high-glucose OES ([glucose] = 405 mM) by suckling or esophageal intubation or 2 L of a commercially available low-glucose OES ([glucose] = 56 mM) by suckling. Abomasal emptying rate was determined by acetaminophen absorption, ultrasonography, and glucose absorption. High-glucose OES rapidly increased plasma glucose concentration after suckling but produced a slower rate of abomasal emptying than did low-glucose OES. Esophageal intubation of high-glucose OES produced the same initial change in abomasal volume as did suckling, but delayed the rate of OES delivery to the small intestine. Our results suggest that suckling a low-glucose OES provides the fastest rate of abomasal emptying and plasma volume expansion, whereas a high-glucose OES provides the most appropriate oral solution for treating hypoglycemic calves.