Characteristics and outcomes of patients with COVID-19 admitted to ICU in a tertiary hospital in Stockholm, Sweden.
Characteristics and outcomes of patients with COVID-19 admitted to ICU in a tertiary hospital in Stockholm, Sweden.
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DOI：
10.1111/aas.13694
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发表时间：
2021-01
影响因子：
2.1
通讯作者：
Karolinska Intensive Care COVID-19 Study Group
中科院分区：
文献类型：
--
作者：
Larsson E;Brattström O;Agvald-Öhman C;Grip J;Campoccia Jalde F;Strålin K;Nauclér P;Oldner A;Konrad D;Persson BP;Eriksson LI;Mårtensson J;Karolinska Intensive Care COVID-19 Study Group
关于重症监护病房（ICU）COVID-19患者的特征和结局的信息仍然有限。我们研究了入住ICU的COVID-19患者的特征、临床病程和早期结局。我们纳入了2020年3月9日至4月20日期间在卡罗林斯卡大学医院（瑞典斯德哥尔摩）9个ICU住院的所有260名COVID-19患者。主要结局为截至2020年4月30日（研究终点）结局明确（从ICU出院或死亡）的患者的院内死亡率。次要结局包括ICU住院时间、接受机械通气和肾脏替代治疗的患者比例以及出院目的地。在260例COVID-19 ICU患者中，208例（80.0%）为男性，中位年龄为59（IQR 51 - 65）岁，154例（59.2%）至少有一种合并症，入住ICU前症状的中位持续时间为11（IQR 8 - 14）天。研究终点时，62例（23.8%）患者仍留在ICU。在198例明确结局的患者中，ICU住院时间为12（IQR，6 - 18）天，163 82.3%接受机械通气，28（14.1%）接受肾脏替代治疗，60（30.3%）死亡，62例（31.3%）出院回家，47例（23.7%）出院到病房，29例（14.6%）出院到其他医疗机构。多因素Logistic回归分析显示，年龄较大和急诊入院与死亡率较高相关。本研究提供了瑞典一家大型三级医院ICU收治的连续COVID-19患者的临床特征和早期结局的详细数据。
Information on characteristics and outcomes of intensive care unit (ICU) patients with COVID‐19 remains limited. We examined characteristics, clinical course and early outcomes of patients with COVID‐19 admitted to ICU. We included all 260 patients with COVID‐19 admitted to nine ICUs at the Karolinska University Hospital (Stockholm, Sweden) between 9 March and 20 April 2020. Primary outcome was in‐hospital mortality among patients with definite outcomes (discharged from ICU or death), as of 30 April 2020 (study end point). Secondary outcomes included ICU length of stay, the proportion of patients receiving mechanical ventilation and renal replacement therapy, and hospital discharge destination. Of 260 ICU patients with COVID‐19, 208 (80.0%) were men, the median age was 59 (IQR 51‐65) years, 154 (59.2%) had at least one comorbidity, and the median duration of symptoms preceding ICU admission was 11 (IQR 8‐14) days. Sixty‐two (23.8%) patients remained in ICU at study end point. Among the 198 patients with definite outcomes, ICU length of stay was 12 (IQR, 6‐18) days, 163 (82.3%) received mechanical ventilation, 28 (14.1%) received renal replacement therapy, 60 (30.3%) died, 62 (31.3%) were discharged home, 47 (23.7%) were discharged to ward, and 29 (14.6%) were discharged to another health care facility. On multivariable logistic regression analysis, older age and admission from the emergency department was associated with higher mortality. This study presents detailed data on clinical characteristics and early outcomes of consecutive patients with COVID‐19 admitted to ICU in a large tertiary hospital in Sweden.
DOI：
10.1001/jama.2020.6775
发表时间：
2020-01-01
期刊：
JAMA, Journal of the American Medical Association
影响因子：
--
作者：
Richardson, Safiya;Hirsch, Jamie S.;,
通讯作者：
,
影响因子：
38.9
作者：
Rhodes, A.;Ferdinande, P.;Moreno, R. P.
通讯作者：
Moreno, R. P.