Emergence of a convex trade-off between transmission and virulence
Emergence of a convex trade-off between transmission and virulence
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DOI：
10.1086/430053
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发表时间：
2005-06-01
影响因子：
2.9
通讯作者：
van Baalen, M
中科院分区：
文献类型：
--
作者：
Alizon, S;van Baalen, M
大多数毒力进化模型都假设寄生虫不可能在不对宿主造成更大伤害的情况下提高传播率。然而，这种权衡关系的存在最近受到了质疑。在这里，我们研究如何权衡可以出现一个模型，明确纳入主机内的动态。我们发现，存在性和凸性的权衡是强大的，这意味着一定程度的进化稳定毒力（ESV）的寄生虫。然而，我们也表明，ESV的参数值的依赖性可能是非常强的。这种敏感性的一个可能后果是，在人群中观察到的传播和毒力之间的关系不需要符合基于共同（固定）权衡的预期模式。我们讨论了可能的实验和影响，我们的研究结果的发展毒力管理策略。
Most models of virulence evolution assume that a parasite cannot raise its transmission rate without causing more harm to its host. However, the existence of such trade-off relationships has recently been challenged. Here, we study how a trade-off can emerge from a model that explicitly incorporates within-host dynamics. We find that the existence and the convexity of the trade-off are robust, which implies a definite level of evolutionarily stable virulence (ESV) for the parasite. However, we also show that the dependence of the ESV on parameter values may be very strong. One possible consequence of this sensitivity is that relationships between transmission and virulence observed across populations need not conform to the patterns expected on the basis of a common (fixed) trade-off. We discuss possible experiments and implications of our results for the development of virulence management strategies.