Selection for human immunodeficiency virus type I envelope glycosylation variants with shorter V1-V2 loop sequences occurs during transmission of certain genetic subtypes and may impact viral RNA levels
Selection for human immunodeficiency virus type I envelope glycosylation variants with shorter V1-V2 loop sequences occurs during transmission of certain genetic subtypes and may impact viral RNA levels
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DOI：
10.1128/jvi.79.10.6528-6531.2005
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发表时间：
2005-05-01
影响因子：
5.4
通讯作者：
Overbaugh, J
中科院分区：
文献类型：
--
作者：
Chohan, B;Lang, D;Overbaugh, J
设计一种有效的人类免疫缺陷病毒1型(HIV-1)疫苗将取决于了解在无数流行的HIV-1毒株中哪些变种最常传播，并确定这些变种是否有致命弱点。在这里，我们表明，异性获得的A亚型HIV-1包膜具有签名序列，包括较短的V1-V2环序列和较少的预测N-连接糖基化位点，相对于循环变异的总体群体。相比之下，最近传播的B亚型变异体没有，对于主要危险因素是同性恋接触的病例和异性接触的病例都是如此。这表明在HIV-1传播过程中的选择可能会因感染亚型的不同而不同。有来自23名A亚型感染妇女的证据，对她们来说，有纵向数据表明，那些感染了V1-V2中潜在N连接糖基化位点较少的病毒的人，病毒设定点水平较低。因此，我们的研究还表明，感染病毒的糖基化程度可能会影响疾病的进展。
Designing an effective human immunodeficiency virus type 1 (HIV-1) vaccine will rely on understanding which variants, from among the myriad of circulating HIV-1 strains, are most commonly transmitted and determining whether such variants have an Achilles heel. Here we show that heterosexually acquired subtype A HIV-1 envelopes have signature sequences that include shorter V1-V2 loop sequences and fewer predicted N-linked glycosylation sites relative to the overall population of circulating variants. In contrast, recently transmitted subtype B variants did not, and this was true for cases where the major risk factor was homosexual contact, as well as for cases where it was heterosexual contact. This suggests that selection during HIV-1 transmission may vary depending on the infecting subtype. There was evidence from 23 subtype A-infected women for whom there was longitudinal data that those who were infected with viruses with fewer potential N-linked glycosylation sites in V1-V2 had lower viral set point levels. Thus, our study also suggests that the extent of glycosylation in the infecting virus could impact disease progression.