WHY PATIENTS CHOOSE PARACETAMOL FOR SELF-POISONING AND THEIR KNOWLEDGE OF ITS DANGERS
WHY PATIENTS CHOOSE PARACETAMOL FOR SELF-POISONING AND THEIR KNOWLEDGE OF ITS DANGERS
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DOI：
10.1136/bmj.310.6973.164
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发表时间：
1995-01-21
影响因子：
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通讯作者：
WEITZEL, H
中科院分区：
文献类型：
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作者：
HAWTON, K;WARE, C;WEITZEL, H
扑热息痛是故意自我中毒中最常用的物质。 1 因此，对乙酰氨基酚引起的肝毒性占所有因暴发性肝功能衰竭而转至肝病单位的病例的一半以上，2 是英国每年至少 150 例死亡的明确原因 3，现在是肝移植的一个重要原因。 4人们选择扑热息痛进行自我中毒的原因以及对其影响的了解很少有研究。大约 20 年前，一项针对伦敦国王学院医院（一家针对肝脏问题患者的三级转诊中心）收治的扑热息痛自我中毒患者的研究表明，大多数患者并不知道扑热息痛服用过量会产生危险。 5 这项研究是在扑热息痛自中毒比现在少得多的时候进行的，而且在这种现象得到大量宣传之前。我们进行本研究是为了确定目前因扑热息痛而导致自身中毒的患者选择扑热息痛的原因以及他们对其危险的认识。
Paracetamol is the most commonly used substance in deliberate self poisoning. 1 As a result, hepatic toxicity due to paracetamol accounts for over half of all cases referred to liver units because of fulminant liver failure, 2 is the definite cause of at least 150 deaths a year in the United Kingdom 3 and is now an important reason for liver transplanation. 4The reasons why people choose paracetamol for self poisoning and their understanding of its effects have been little studied. Nearly 20 years ago a study of patients with self poisoning by paracetamol admitted to London's King's College Hospital—a tertiary referral centre for patients with liver problems—showed that most patients did not know that paracetamol was dangerous in overdose. 5 That study was conducted when self poisoning with paracetamol was much less common than it is now and before there had been much publicity about the phenomenon. We conducted the present study to determine why current patients with self poisoning by paracetamol choose paracetamol and their awareness of its dangers.