Natural transformation increases the rate of adaptation in the human pathogen helicobacter pylori
Natural transformation increases the rate of adaptation in the human pathogen helicobacter pylori
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DOI：
10.1111/j.1558-5646.2007.00271.x
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发表时间：
2008-01-01
期刊：
影响因子：
3.3
通讯作者：
Phillips, Patrick C.
中科院分区：
文献类型：
--
作者：
Baltrus, David A.;Guillemin, Karen;Phillips, Patrick C.
个体之间的基因交换可以在基因组和种群水平上产生深远的进化影响。这些效应引发了人们对研究重组的特定适应性益处的广泛兴趣。虽然这项工作主要集中在真核生物中性的好处，但假设遗传交换的类似好处适用于真核生物和原核生物。在这里，我们报告了一个直接的测试，这一假设使用自然转化的人类胃病原体幽门螺杆菌作为模式生物。我们表明，遗传交换加速适应一个新的实验室环境内的细菌种群和一般的适应性优势存在自然转化菌株之间发生的同种背景转移时。这一发现表明，有普遍的好处，以适应在真核生物和原核生物，即使潜在的过程是不同的机制。
Gene exchange between individuals can lead to profound evolutionary effects at both the genomic and population levels. These effects have sparked widespread interest in examining the specific adaptive benefits of recombination. Although this work has primarily focused on the benefits of sex in eukaryotes, it is assumed that similar benefits of genetic exchange apply across eukaryotes and prokaryotes. Here we report a direct test of this assumption using the naturally transformable human gastric pathogen Helicobacter pylori as a model organism. We show that genetic exchange accelerates adaptation to a novel laboratory environment within bacterial populations and that a general adaptive advantage exists for naturally transformable strains when transfer occurs among conspecific backgrounds. This finding demonstrates that there are generalized benefits to adaptation in both eukaryotes and prokaryotes even though the underlying processes are mechanistically different.