Proton therapy in combination with PET as monitor: a feasibility study
Proton therapy in combination with PET as monitor: a feasibility study
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质子治疗结合 PET 作为监测器：可行性研究
DOI：
10.1109/nssmic.1992.301094
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
J. Schippers
中科院分区：
文献类型：
--
作者：
A. Paans;J. Schippers
为了评估质子治疗与正电子发射断层扫描（PET）相结合的可能性，作为一种治疗监测和治疗过程中原位剂量测定的工具，质子活化实验已经使用55 MeV质子束在两种不同的材料上进行。与PET的诱导活动的三维测量与计算的剂量分布和模型计算进行比较。结果表明，质子束在类组织（主要由C、N和O组成）材料中引起的放射性可以用PET精确测量。预期可以足够准确地检测在治疗处理期间产生的相当少量的活性;特别地，可以用该方法相当好地监测剂量分布中布拉格峰之前的区域。<<ETX>>
To evaluate the possibility of combining proton therapy with positron emission tomography (PET) as a therapy monitor and as a tool for in situ dosimetry during therapy, proton activation experiments have been performed using a 55-MeV proton beam on two different materials. The three-dimensional measurements of the induced activity with PET are compared with the calculated dose distribution and with model calculations. It is concluded that the radioactivity induced by proton beams in tissue-like (consisting mainly of C, N and O) materials can be measured accurately by means of PET. It is expected that the rather low amount of activity created during a therapy treatment can be detected with sufficient accuracy; in particular, the region preceding the Bragg peak in the dose distribution can be monitored quite well with this method.<<ETX>>