Changes in the fluctuation of interbeat intervals in spontaneously beating cultured cardiac myocytes: experimental and modeling studies
Changes in the fluctuation of interbeat intervals in spontaneously beating cultured cardiac myocytes: experimental and modeling studies
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自发跳动培养心肌细胞心跳间隔波动的变化：实验和模型研究
DOI：
10.1007/s00422-001-0285-y
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发表时间：
2002
影响因子：
1.9
通讯作者：
K. Kawahara
中科院分区：
文献类型：
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作者：
Y. Yamauchi;Akihiko Harada;K. Kawahara
分离和培养的新生儿心肌细胞具有自发性和周期性收缩，并具有非线性振荡器的特性。在本研究中，我们分析了自发搏动培养的心肌细胞收缩节律的波动与它们之间的耦合强度的关系。收缩间期变异系数在孵化初期呈一过性增加，随后随时间几乎单调下降。培养后期，心肌细胞的收缩节律趋于同步。同步发生的那一天几乎与变异系数达到最低值的那一天重合。此外，我们使用相互作用的Bonhoeffer-van der Pol振荡器进行了数学分析，以阐明收缩节律随时间波动的潜在机制。随着振子间耦合强度的增加，振荡周期的变异系数暂时增大，但当振子同步时又迅速减小。这些结果提示，搏动节律波动的改变是自发性搏动心肌细胞间电耦合强度增强的结果。
Isolated and cultured neonatal cardiac myocytes contract spontaneously and cyclically, and have the properties of a non-linear oscillator. In this study, we have analyzed the relationship between the fluctuation of contraction rhythm of spontaneously beating cultured cardiac myocytes, and the coupling strength among them. The coefficient of variation of contraction intervals increased transiently in the early stages of incubation, and then decreased almost monotonically with time. The contraction rhythm of the myocytes became synchronized in the late stage of the culture. The day on which synchronization occurred almost coincided with the day when the coefficient of variation reached its lowest value. In addition, we have performed a mathematical analysis using interacting Bonhoeffer–van der Pol oscillators to clarify the mechanisms underlying the changes in the fluctuation of contraction rhythm with time. As the coupling strength among oscillators increased, the coefficient of variation of oscillation periods increased temporarily, but then decreased rapidly when the oscillators showed synchronization. These results suggest that the changes in the fluctuation of beating rhythm result from the increase in strength of electrical coupling among spontaneously beating cardiac myocytes.
Koichi KAWAHARA：“去大脑猫虚构运动过程中的心跳波动：中枢起源的运动-心脏耦合。”
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