Volumetric neural correlates of antisaccade eye movements in first-episode psychosis
Volumetric neural correlates of antisaccade eye movements in first-episode psychosis
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DOI：
10.1176/appi.ajp.161.10.1918
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发表时间：
2004-10-01
影响因子：
17.7
通讯作者：
Sharma, T
中科院分区：
文献类型：
--
作者：
Ettinger, U;Kumari, V;Sharma, T
目的：探讨脑部结构与抗眼跳能力的相关性。方法：采用磁共振成像技术测量20例首发精神病患者和18例健康对照组的前额叶、前运动区、感觉运动区、枕顶叶皮质以及尾状核、丘脑、小脑虫和大脑的体积。结果：两组在抗扫视错误率和幅度增益方面有显著差异，在潜伏期方面也有差异，但在脑区体积方面没有差异。在对照受试者中，运动前皮质体积可预测抗眼跳错误率。在患者组中，尾状核体积与潜伏期和波幅增益相关。阴性症状，独立于结构体积，预测错误率。结论：这些发现指出了首发精神病患者结构-功能关系的改变。
Objective: The authors investigated the structural brain correlates of antisaccade performance.Method: Magnetic resonance imaging was used to measure the volumes of the prefrontal, premotor, sensorimotor, and occipitoparietal cortices as well as the caudate, thalamus, cerebellar vermis, and cerebrum in 20 first-episode psychosis patients and 18 healthy comparison subjects. Antisaccades were recorded by using infrared oculography.Results: Groups significantly differed in terms of antisaccade error rate and amplitude gain and tended to differ in terms of latency but not brain region volumes. Premotor cortex volume predicted antisaccade error rate among comparison subjects. In the patient group, caudate volume was related to latency and amplitude gain. Negative symptoms, independent of structural volumes, predicted error rate.Conclusions: These findings point to altered structure-function relationships in first-episode psychosis.