Low doses of haloperidol interfere with rat tongue extensions during licking: a quantitative analysis.
Low doses of haloperidol interfere with rat tongue extensions during licking: a quantitative analysis.
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低剂量的氟哌啶醇会干扰大鼠舔舐过程中的舌头伸展：定量分析。
DOI：
10.1037//0735-7044.106.2.386
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发表时间：
1992
影响因子：
1.9
通讯作者：
Mortell,C
中科院分区：
文献类型：
--
作者：
Fowler,SC;Mortell,C
氟哌啶醇对口舌运动障碍的影响被研究在大鼠训练舔水滴从力感应盘。氟哌啶醇剂量依赖性地减少舌突力，减少舔舐持续时间，增加舔舐间隔，减少舔舐次数。傅里叶方法表明，氟哌啶醇在低至0.06 mg/kg的剂量下，将舔振荡从平均5.250 Hz减慢到5.096 Hz (p=。014)。舔力可以通过水滴传递来调节，但氟哌啶醇不影响这种效果，这表明药物没有干扰舔的感觉调节。药物引起的舌力缺陷可能是体位改变（假性帕金森氏症）或口舌运动障碍的表现，或两者兼而有之。多语运动障碍可以解释一些抗精神病药引起的行为下降，这些行为下降以前被解释为奖励、动机缺陷或两者兼而有之。（PsycINFO数据库记录(c) 2016 APA，版权所有）
Orolingual dyskinetic effects of haloperidol were studied in rats trained to lick drops of water from a force-sensing disk. Haloperidol dose-dependently decreased force of tongue protrusion, decreased lick duration, increased interlick interval, and decreased number of licks. Fourier methods showed that haloperidol, in doses as low as 0.06 mg/kg, slowed the lick oscillations from an average of 5.250 Hz to 5.096 Hz (p=. 014). Lick force was modulated by water drop delivery, but this effect was not influenced by haloperidol, which suggests no interference of the drug with sensory regulation of licking. The drug-induced deficits in tongue force may be manifestations of either postural alterations (pseudoparkinsonism) or orobuccolingual dyskinesias or both. Orolingual motor impairments may account for some of the neuroleptic-engendered behavioral decrements that have previously been explained in terms of reward, motivational deficits, or both.(PsycINFO Database Record (c) 2016 APA, all rights reserved)
反应动力学
DOI：
--
发表时间：
1965
期刊：
影响因子：
--
作者：
J. M. Notterman;D. E. Mintz
通讯作者：
D. E. Mintz