Targeting antitumor CD4 helper T cells with universal tumor-reactive helper peptides derived from telomerase for cancer vaccine
Targeting antitumor CD4 helper T cells with universal tumor-reactive helper peptides derived from telomerase for cancer vaccine
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DOI：
10.4161/hv.23587
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发表时间：
2013-05-01
影响因子：
4.8
通讯作者：
Borg, Christophe
中科院分区：
文献类型：
--
作者：
Adotevi, Olivier;Dosset, Magalie;Borg, Christophe
目前的癌症免疫疗法主要依靠CD8(+) T细胞来对抗肿瘤。然而，越来越多的证据表明，促炎性 CD4+ 辅助 T 细胞是有效抗肿瘤免疫的关键决定因素。利用来自端粒酶的通用肿瘤反应性辅助肽代表了充分利用基于 CD4(+) T 细胞的免疫疗法的强大方法。
Current cancer immunotherapies predominantly rely on CD8(+) T cells to fight against tumors. However accumulative evidence showed that proinflammatory CD4(+) helper T cells are critical determinants of effective antitumor immunity. The utilization of universal tumor-reactive helper peptides from telomerase represents a powerful approach to the fully use of CD4(+) T cell-based immunotherapy.